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Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma

Metastatic melanoma is one of the deadliest of skin cancers and is increasing in incidence. Since current treatment regimens are ineffective at controlling and/or curing the disease, novel approaches, such as immunotherapy, for treating this malignant disease are being explored. In this review, we d...

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Detalles Bibliográficos
Autores principales: Norton, Duncan L., Haque, Azizul
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792950/
https://www.ncbi.nlm.nih.gov/pubmed/20016802
http://dx.doi.org/10.1155/2009/142959
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author Norton, Duncan L.
Haque, Azizul
author_facet Norton, Duncan L.
Haque, Azizul
author_sort Norton, Duncan L.
collection PubMed
description Metastatic melanoma is one of the deadliest of skin cancers and is increasing in incidence. Since current treatment regimens are ineffective at controlling and/or curing the disease, novel approaches, such as immunotherapy, for treating this malignant disease are being explored. In this review, we discuss potential melanoma antigens (Ags) and their role in utilizing the HLA class II pathway to elicit tumor Ag-specific CD4+ T cell responses in order to effectively induce long-lasting CD8+ antitumor memory. We also discuss the role of endolysosomal cathepsins and Gamma-Interferon-inducible Lysosomal Thiol reductase (GILT) in Ag processing and presentation, and at enhancing CD4+ T cell recognition of melanoma cells. This review also summarizes our current knowledge on GILT and highlights a novel mechanism of GILT-mediated immune responses against melanoma cells. At the end, we propose a strategy employing GILT in the development of a potential whole cell vaccine for combating metastatic melanoma.
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spelling pubmed-27929502009-12-16 Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma Norton, Duncan L. Haque, Azizul J Oncol Review Article Metastatic melanoma is one of the deadliest of skin cancers and is increasing in incidence. Since current treatment regimens are ineffective at controlling and/or curing the disease, novel approaches, such as immunotherapy, for treating this malignant disease are being explored. In this review, we discuss potential melanoma antigens (Ags) and their role in utilizing the HLA class II pathway to elicit tumor Ag-specific CD4+ T cell responses in order to effectively induce long-lasting CD8+ antitumor memory. We also discuss the role of endolysosomal cathepsins and Gamma-Interferon-inducible Lysosomal Thiol reductase (GILT) in Ag processing and presentation, and at enhancing CD4+ T cell recognition of melanoma cells. This review also summarizes our current knowledge on GILT and highlights a novel mechanism of GILT-mediated immune responses against melanoma cells. At the end, we propose a strategy employing GILT in the development of a potential whole cell vaccine for combating metastatic melanoma. Hindawi Publishing Corporation 2009 2009-11-24 /pmc/articles/PMC2792950/ /pubmed/20016802 http://dx.doi.org/10.1155/2009/142959 Text en Copyright © 2009 D. L. Norton and A. Haque. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Norton, Duncan L.
Haque, Azizul
Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
title Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
title_full Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
title_fullStr Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
title_full_unstemmed Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
title_short Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
title_sort insights into the role of gilt in hla class ii antigen processing and presentation by melanoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792950/
https://www.ncbi.nlm.nih.gov/pubmed/20016802
http://dx.doi.org/10.1155/2009/142959
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