Physiological and Oncogenic Aurora-A Pathway

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A ind...

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Detalles Bibliográficos
Autores principales: SAEKI, Toshiaki, OUCHI, Mutsuko, OUCHI, Toru
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793309/
https://www.ncbi.nlm.nih.gov/pubmed/20011137
Descripción
Sumario:Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.

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