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Physiological and Oncogenic Aurora-A Pathway
Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A ind...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793309/ https://www.ncbi.nlm.nih.gov/pubmed/20011137 |
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author | SAEKI, Toshiaki OUCHI, Mutsuko OUCHI, Toru |
author_facet | SAEKI, Toshiaki OUCHI, Mutsuko OUCHI, Toru |
author_sort | SAEKI, Toshiaki |
collection | PubMed |
description | Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis. |
format | Text |
id | pubmed-2793309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-27933092009-12-15 Physiological and Oncogenic Aurora-A Pathway SAEKI, Toshiaki OUCHI, Mutsuko OUCHI, Toru Int J Biol Sci Review Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis. Ivyspring International Publisher 2009-11-26 /pmc/articles/PMC2793309/ /pubmed/20011137 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Review SAEKI, Toshiaki OUCHI, Mutsuko OUCHI, Toru Physiological and Oncogenic Aurora-A Pathway |
title | Physiological and Oncogenic Aurora-A Pathway |
title_full | Physiological and Oncogenic Aurora-A Pathway |
title_fullStr | Physiological and Oncogenic Aurora-A Pathway |
title_full_unstemmed | Physiological and Oncogenic Aurora-A Pathway |
title_short | Physiological and Oncogenic Aurora-A Pathway |
title_sort | physiological and oncogenic aurora-a pathway |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793309/ https://www.ncbi.nlm.nih.gov/pubmed/20011137 |
work_keys_str_mv | AT saekitoshiaki physiologicalandoncogenicauroraapathway AT ouchimutsuko physiologicalandoncogenicauroraapathway AT ouchitoru physiologicalandoncogenicauroraapathway |