Physiological and Oncogenic Aurora-A Pathway

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A ind...

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Detalles Bibliográficos
Autores principales: SAEKI, Toshiaki, OUCHI, Mutsuko, OUCHI, Toru
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793309/
https://www.ncbi.nlm.nih.gov/pubmed/20011137
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author SAEKI, Toshiaki
OUCHI, Mutsuko
OUCHI, Toru
author_facet SAEKI, Toshiaki
OUCHI, Mutsuko
OUCHI, Toru
author_sort SAEKI, Toshiaki
collection PubMed
description Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.
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spelling pubmed-27933092009-12-15 Physiological and Oncogenic Aurora-A Pathway SAEKI, Toshiaki OUCHI, Mutsuko OUCHI, Toru Int J Biol Sci Review Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis. Ivyspring International Publisher 2009-11-26 /pmc/articles/PMC2793309/ /pubmed/20011137 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
SAEKI, Toshiaki
OUCHI, Mutsuko
OUCHI, Toru
Physiological and Oncogenic Aurora-A Pathway
title Physiological and Oncogenic Aurora-A Pathway
title_full Physiological and Oncogenic Aurora-A Pathway
title_fullStr Physiological and Oncogenic Aurora-A Pathway
title_full_unstemmed Physiological and Oncogenic Aurora-A Pathway
title_short Physiological and Oncogenic Aurora-A Pathway
title_sort physiological and oncogenic aurora-a pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793309/
https://www.ncbi.nlm.nih.gov/pubmed/20011137
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