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Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 Mice

BACKGROUND: Lupus nephritis is characterized by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes (GBM). The latter defines end-stage disease. METHODOLOGY/PRINCIPALS: In the present study we determined the impact of antibodies to dsDNA, renal Dn...

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Detalles Bibliográficos
Autores principales:	Fenton, Kristin, Fismen, Silje, Hedberg, Annica, Seredkina, Natalya, Fenton, Chris, Mortensen, Elin Synnøve, Rekvig, Ole Petter
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793523/ https://www.ncbi.nlm.nih.gov/pubmed/20041189 http://dx.doi.org/10.1371/journal.pone.0008474

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