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Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for its role in Alzheimer's disease as the β-secretase responsible for gener...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793532/ https://www.ncbi.nlm.nih.gov/pubmed/20041192 http://dx.doi.org/10.1371/journal.pone.0008477 |