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Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for its role in Alzheimer's disease as the β-secretase responsible for gener...

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Detalles Bibliográficos
Autores principales:	Hemming, Matthew L., Elias, Joshua E., Gygi, Steven P., Selkoe, Dennis J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793532/ https://www.ncbi.nlm.nih.gov/pubmed/20041192 http://dx.doi.org/10.1371/journal.pone.0008477

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