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The 3′–5′ proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases

Archaeal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single-stranded DNA, stalling replication on encountering these pro-mutagenic deoxynucleosides four steps ahead of the primer–template junction. When uracil is specifically bound, the polymerase–DNA complex...

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Detalles Bibliográficos
Autores principales:	Russell, Henry J., Richardson, Tomas T., Emptage, Kieran, Connolly, Bernard A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794169/ https://www.ncbi.nlm.nih.gov/pubmed/19783818 http://dx.doi.org/10.1093/nar/gkp800

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