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Expanded RNA-binding activities of mammalian Argonaute 2

Mammalian Argonaute 2 (Ago2) protein associates with microRNAs (miRNAs) or small interfering RNAs (siRNAs) forming RNA-induced silencing complexes (RISCs/miRNPs). In the present work, we characterize the RNA-binding and nucleolytic activity of recombinant mouse Ago2. Our studies show that recombinan...

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Detalles Bibliográficos
Autores principales:	Tan, Grace S., Garchow, Barry G., Liu, Xuhang, Yeung, Jennifer, Morris, John P., Cuellar, Trinna L., McManus, Michael T., Kiriakidou, Marianthi
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794174/ https://www.ncbi.nlm.nih.gov/pubmed/19808937 http://dx.doi.org/10.1093/nar/gkp812

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