DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2

A subtelomeric region, 4q35.2, is implicated in facioscapulohumeral muscular dystrophy (FSHD), a dominant disease thought to involve local pathogenic changes in chromatin. FSHD patients have too few copies of a tandem 3.3-kb repeat (D4Z4) at 4q35.2. No phenotype is associated with having few copies...

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Detalles Bibliográficos
Autores principales: Xu, Xueqing, Tsumagari, Koji, Sowden, Janet, Tawil, Rabi, Boyle, Alan P., Song, Lingyun, Furey, Terrence S., Crawford, Gregory E., Ehrlich, Melanie
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794184/
https://www.ncbi.nlm.nih.gov/pubmed/19820107
http://dx.doi.org/10.1093/nar/gkp833

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