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Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

In the search for new therapeutics for the treatment of human African trypanosomiasis, many potential drug targets in Trypanosoma brucei have been validated by genetic means, but very few have been chemically validated. Trypanothione synthetase (TryS; EC 6.3.1.9; spermidine/glutathionylspermidine:gl...

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Detalles Bibliográficos
Autores principales:	Torrie, Leah S., Wyllie, Susan, Spinks, Daniel, Oza, Sandra L., Thompson, Stephen, Harrison, Justin R., Gilbert, Ian H., Wyatt, Paul G., Fairlamb, Alan H., Frearson, Julie A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794729/ https://www.ncbi.nlm.nih.gov/pubmed/19828449 http://dx.doi.org/10.1074/jbc.M109.045336

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