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Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells

BACKGROUND: Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts. METHOD: Selenium-enriched broccol...

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Autores principales: Abdulah, Rizky, Faried, Ahmad, Kobayashi, Kenji, Yamazaki, Chiho, Suradji, Eka W, Ito, Kazuto, Suzuki, Kazuhiro, Murakami, Masami, Kuwano, Hiroyuki, Koyama, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794877/
https://www.ncbi.nlm.nih.gov/pubmed/19943972
http://dx.doi.org/10.1186/1471-2407-9-414
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author Abdulah, Rizky
Faried, Ahmad
Kobayashi, Kenji
Yamazaki, Chiho
Suradji, Eka W
Ito, Kazuto
Suzuki, Kazuhiro
Murakami, Masami
Kuwano, Hiroyuki
Koyama, Hiroshi
author_facet Abdulah, Rizky
Faried, Ahmad
Kobayashi, Kenji
Yamazaki, Chiho
Suradji, Eka W
Ito, Kazuto
Suzuki, Kazuhiro
Murakami, Masami
Kuwano, Hiroyuki
Koyama, Hiroshi
author_sort Abdulah, Rizky
collection PubMed
description BACKGROUND: Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts. METHOD: Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract. RESULTS: Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway. CONCLUSION: Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy.
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spelling pubmed-27948772009-12-17 Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells Abdulah, Rizky Faried, Ahmad Kobayashi, Kenji Yamazaki, Chiho Suradji, Eka W Ito, Kazuto Suzuki, Kazuhiro Murakami, Masami Kuwano, Hiroyuki Koyama, Hiroshi BMC Cancer Research Article BACKGROUND: Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts. METHOD: Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract. RESULTS: Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway. CONCLUSION: Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy. BioMed Central 2009-11-30 /pmc/articles/PMC2794877/ /pubmed/19943972 http://dx.doi.org/10.1186/1471-2407-9-414 Text en Copyright ©2009 Abdulah et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Abdulah, Rizky
Faried, Ahmad
Kobayashi, Kenji
Yamazaki, Chiho
Suradji, Eka W
Ito, Kazuto
Suzuki, Kazuhiro
Murakami, Masami
Kuwano, Hiroyuki
Koyama, Hiroshi
Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
title Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
title_full Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
title_fullStr Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
title_full_unstemmed Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
title_short Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
title_sort selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of lncap prostate cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794877/
https://www.ncbi.nlm.nih.gov/pubmed/19943972
http://dx.doi.org/10.1186/1471-2407-9-414
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