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Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008

BACKGROUND: Recent population-based estimates in a Dhaka low-income community suggest that influenza was prevalent among children. To explore the epidemiology and seasonality of influenza throughout the country and among all age groups, we established nationally representative hospital-based surveil...

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Autores principales: Zaman, Rashid Uz, Alamgir, A. S. M., Rahman, Mustafizur, Azziz-Baumgartner, Eduardo, Gurley, Emily S., Sharker, M. Abu Yushuf, Brooks, W. Abdullah, Azim, Tasnim, Fry, Alicia M., Lindstrom, Stephen, Gubareva, Larisa V., Xu, Xiyan, Garten, Rebecca J., Hossain, M. Jahangir, Khan, Salah Uddin, Faruque, Labib Imran, Ameer, Syeda Shegufta, Klimov, Alexander I., Rahman, Mahmudur, Luby, Stephen P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795194/
https://www.ncbi.nlm.nih.gov/pubmed/20041114
http://dx.doi.org/10.1371/journal.pone.0008452
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author Zaman, Rashid Uz
Alamgir, A. S. M.
Rahman, Mustafizur
Azziz-Baumgartner, Eduardo
Gurley, Emily S.
Sharker, M. Abu Yushuf
Brooks, W. Abdullah
Azim, Tasnim
Fry, Alicia M.
Lindstrom, Stephen
Gubareva, Larisa V.
Xu, Xiyan
Garten, Rebecca J.
Hossain, M. Jahangir
Khan, Salah Uddin
Faruque, Labib Imran
Ameer, Syeda Shegufta
Klimov, Alexander I.
Rahman, Mahmudur
Luby, Stephen P.
author_facet Zaman, Rashid Uz
Alamgir, A. S. M.
Rahman, Mustafizur
Azziz-Baumgartner, Eduardo
Gurley, Emily S.
Sharker, M. Abu Yushuf
Brooks, W. Abdullah
Azim, Tasnim
Fry, Alicia M.
Lindstrom, Stephen
Gubareva, Larisa V.
Xu, Xiyan
Garten, Rebecca J.
Hossain, M. Jahangir
Khan, Salah Uddin
Faruque, Labib Imran
Ameer, Syeda Shegufta
Klimov, Alexander I.
Rahman, Mahmudur
Luby, Stephen P.
author_sort Zaman, Rashid Uz
collection PubMed
description BACKGROUND: Recent population-based estimates in a Dhaka low-income community suggest that influenza was prevalent among children. To explore the epidemiology and seasonality of influenza throughout the country and among all age groups, we established nationally representative hospital-based surveillance necessary to guide influenza prevention and control efforts. METHODOLGY/PRINCIPAL FINDINGS: We conducted influenza-like illness and severe acute respiratory illness sentinel surveillance in 12 hospitals across Bangladesh during May 2007–December 2008. We collected specimens from 3,699 patients, 385 (10%) which were influenza positive by real time RT-PCR. Among the sample-positive patients, 192 (51%) were type A and 188 (49%) were type B. Hemagglutinin subtyping of type A viruses detected 137 (71%) A/H1 and 55 (29%) A/H3, but no A/H5 or other novel influenza strains. The frequency of influenza cases was highest among children aged under 5 years (44%), while the proportions of laboratory confirmed cases was highest among participants aged 11–15 (18%). We applied kriging, a geo-statistical technique, to explore the spatial and temporal spread of influenza and found that, during 2008, influenza was first identified in large port cities and then gradually spread to other parts of the country. We identified a distinct influenza peak during the rainy season (May–September). CONCLUSIONS/SIGNIFICANCE: Our surveillance data confirms that influenza is prevalent throughout Bangladesh, affecting a wide range of ages and causing considerable morbidity and hospital care. A unimodal influenza seasonality may allow Bangladesh to time annual influenza prevention messages and vaccination campaigns to reduce the national influenza burden. To scale-up such national interventions, we need to quantify the national rates of influenza and the economic burden associated with this disease through further studies.
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spelling pubmed-27951942009-12-30 Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008 Zaman, Rashid Uz Alamgir, A. S. M. Rahman, Mustafizur Azziz-Baumgartner, Eduardo Gurley, Emily S. Sharker, M. Abu Yushuf Brooks, W. Abdullah Azim, Tasnim Fry, Alicia M. Lindstrom, Stephen Gubareva, Larisa V. Xu, Xiyan Garten, Rebecca J. Hossain, M. Jahangir Khan, Salah Uddin Faruque, Labib Imran Ameer, Syeda Shegufta Klimov, Alexander I. Rahman, Mahmudur Luby, Stephen P. PLoS One Research Article BACKGROUND: Recent population-based estimates in a Dhaka low-income community suggest that influenza was prevalent among children. To explore the epidemiology and seasonality of influenza throughout the country and among all age groups, we established nationally representative hospital-based surveillance necessary to guide influenza prevention and control efforts. METHODOLGY/PRINCIPAL FINDINGS: We conducted influenza-like illness and severe acute respiratory illness sentinel surveillance in 12 hospitals across Bangladesh during May 2007–December 2008. We collected specimens from 3,699 patients, 385 (10%) which were influenza positive by real time RT-PCR. Among the sample-positive patients, 192 (51%) were type A and 188 (49%) were type B. Hemagglutinin subtyping of type A viruses detected 137 (71%) A/H1 and 55 (29%) A/H3, but no A/H5 or other novel influenza strains. The frequency of influenza cases was highest among children aged under 5 years (44%), while the proportions of laboratory confirmed cases was highest among participants aged 11–15 (18%). We applied kriging, a geo-statistical technique, to explore the spatial and temporal spread of influenza and found that, during 2008, influenza was first identified in large port cities and then gradually spread to other parts of the country. We identified a distinct influenza peak during the rainy season (May–September). CONCLUSIONS/SIGNIFICANCE: Our surveillance data confirms that influenza is prevalent throughout Bangladesh, affecting a wide range of ages and causing considerable morbidity and hospital care. A unimodal influenza seasonality may allow Bangladesh to time annual influenza prevention messages and vaccination campaigns to reduce the national influenza burden. To scale-up such national interventions, we need to quantify the national rates of influenza and the economic burden associated with this disease through further studies. Public Library of Science 2009-12-29 /pmc/articles/PMC2795194/ /pubmed/20041114 http://dx.doi.org/10.1371/journal.pone.0008452 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Zaman, Rashid Uz
Alamgir, A. S. M.
Rahman, Mustafizur
Azziz-Baumgartner, Eduardo
Gurley, Emily S.
Sharker, M. Abu Yushuf
Brooks, W. Abdullah
Azim, Tasnim
Fry, Alicia M.
Lindstrom, Stephen
Gubareva, Larisa V.
Xu, Xiyan
Garten, Rebecca J.
Hossain, M. Jahangir
Khan, Salah Uddin
Faruque, Labib Imran
Ameer, Syeda Shegufta
Klimov, Alexander I.
Rahman, Mahmudur
Luby, Stephen P.
Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008
title Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008
title_full Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008
title_fullStr Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008
title_full_unstemmed Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008
title_short Influenza in Outpatient ILI Case-Patients in National Hospital-Based Surveillance, Bangladesh, 2007–2008
title_sort influenza in outpatient ili case-patients in national hospital-based surveillance, bangladesh, 2007–2008
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795194/
https://www.ncbi.nlm.nih.gov/pubmed/20041114
http://dx.doi.org/10.1371/journal.pone.0008452
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