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Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10

All-in-one admixtures (AIO-admixtures) provide safe, effective and low-risk PN (parenteral nutrition) for practically all indications and applications. Water, energy (carbohydrates and lipids), amino acids, vitamins and trace elements are infused together with PN either as industrially-manufactured...

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Detalles Bibliográficos
Autores principales: Mühlebach, S., Franken, C., Stanga, Z.
Formato: Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795373/
https://www.ncbi.nlm.nih.gov/pubmed/20049073
http://dx.doi.org/10.3205/000077
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author Mühlebach, S.
Franken, C.
Stanga, Z.
author_facet Mühlebach, S.
Franken, C.
Stanga, Z.
author_sort Mühlebach, S.
collection PubMed
description All-in-one admixtures (AIO-admixtures) provide safe, effective and low-risk PN (parenteral nutrition) for practically all indications and applications. Water, energy (carbohydrates and lipids), amino acids, vitamins and trace elements are infused together with PN either as industrially-manufactured AIO admixtures provided as two- or three-chamber bags (shelf life usually more than 12 months) completed with electrolytes and micronutrients where appropriate or as individually compounded ready-to-use AIO admixtures (compounding, usually prepared by a pharmacy on either a daily or weekly basis and stored at 2–8°C). Physico-chemical and microbial stability of an AIO admixture is essential for the safety and effectiveness of patient-specific PN, and its assurance requires specialist pharmaceutical knowledge. The stability should be documented for an application period of 24 (–48) hours. It is advisable to offer a limited selection of different PN regimes in each hospital. For reasons of drug and medication safety, PN admixtures prepared for individual patients must be correctly labelled and specifications for storage conditions must also be followed during transport. Monitoring is required where applicable. Micronutrients are usually administered separately to AIO admixtures. In case compatibility and stability have been well documented trace elements and/or combination preparations including water-soluble or water-soluble/fat soluble vitamin supplements can be added to PN admixtures under strict aseptic conditions. AIO admixtures are usually not used as vehicles for drugs (incompatibilities).
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spelling pubmed-27953732010-01-04 Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10 Mühlebach, S. Franken, C. Stanga, Z. Ger Med Sci Article All-in-one admixtures (AIO-admixtures) provide safe, effective and low-risk PN (parenteral nutrition) for practically all indications and applications. Water, energy (carbohydrates and lipids), amino acids, vitamins and trace elements are infused together with PN either as industrially-manufactured AIO admixtures provided as two- or three-chamber bags (shelf life usually more than 12 months) completed with electrolytes and micronutrients where appropriate or as individually compounded ready-to-use AIO admixtures (compounding, usually prepared by a pharmacy on either a daily or weekly basis and stored at 2–8°C). Physico-chemical and microbial stability of an AIO admixture is essential for the safety and effectiveness of patient-specific PN, and its assurance requires specialist pharmaceutical knowledge. The stability should be documented for an application period of 24 (–48) hours. It is advisable to offer a limited selection of different PN regimes in each hospital. For reasons of drug and medication safety, PN admixtures prepared for individual patients must be correctly labelled and specifications for storage conditions must also be followed during transport. Monitoring is required where applicable. Micronutrients are usually administered separately to AIO admixtures. In case compatibility and stability have been well documented trace elements and/or combination preparations including water-soluble or water-soluble/fat soluble vitamin supplements can be added to PN admixtures under strict aseptic conditions. AIO admixtures are usually not used as vehicles for drugs (incompatibilities). German Medical Science GMS Publishing House 2009-11-18 /pmc/articles/PMC2795373/ /pubmed/20049073 http://dx.doi.org/10.3205/000077 Text en Copyright © 2009 Mühlebach et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Article
Mühlebach, S.
Franken, C.
Stanga, Z.
Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10
title Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10
title_full Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10
title_fullStr Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10
title_full_unstemmed Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10
title_short Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10
title_sort practical handling of aio admixtures – guidelines on parenteral nutrition, chapter 10
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795373/
https://www.ncbi.nlm.nih.gov/pubmed/20049073
http://dx.doi.org/10.3205/000077
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