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Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. METHODS: We have geno...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795432/ https://www.ncbi.nlm.nih.gov/pubmed/19920816 http://dx.doi.org/10.1038/sj.bjc.6605416 |
| _version_ | 1782175431781253120 |
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| author | Osorio, A Milne, R L Pita, G Peterlongo, P Heikkinen, T Simard, J Chenevix-Trench, G Spurdle, A B Beesley, J Chen, X Healey, S Neuhausen, S L Ding, Y C Couch, F J Wang, X Lindor, N Manoukian, S Barile, M Viel, A Tizzoni, L Szabo, C I Foretova, L Zikan, M Claes, K Greene, M H Mai, P Rennert, G Lejbkowicz, F Barnett-Griness, O Andrulis, I L Ozcelik, H Weerasooriya, N Gerdes, A-M Thomassen, M Cruger, D G Caligo, M A Friedman, E Kaufman, B Laitman, Y Cohen, S Kontorovich, T Gershoni-Baruch, R Dagan, E Jernström, H Askmalm, M S Arver, B Malmer, B Domchek, S M Nathanson, K L Brunet, J Ramón y Cajal, T Yannoukakos, D Hamann, U Hogervorst, F B L Verhoef, S García, EB Gómez Wijnen, J T van den Ouweland, A Easton, D F Peock, S Cook, M Oliver, C T Frost, D Luccarini, C Evans, D G Lalloo, F Eeles, R Pichert, G Cook, J Hodgson, S Morrison, P J Douglas, F Godwin, A K Sinilnikova, O M Barjhoux, L Stoppa-Lyonnet, D Moncoutier, V Giraud, S Cassini, C Olivier-Faivre, L Révillion, F Peyrat, J-P Muller, D Fricker, J-P Lynch, H T John, E M Buys, S Daly, M Hopper, J L Terry, M B Miron, A Yassin, Y Goldgar, D Singer, C F Gschwantler-Kaulich, D Pfeiler, G Spiess, A-C Hansen, Thomas v O Johannsson, O T Kirchhoff, T Offit, K Kosarin, K Piedmonte, M Rodriguez, G C Wakeley, K Boggess, J F Basil, J Schwartz, P E Blank, S V Toland, A E Montagna, M Casella, C Imyanitov, E N Allavena, A Schmutzler, R K Versmold, B Engel, C Meindl, A Ditsch, N Arnold, N Niederacher, D Deißler, H Fiebig, B Varon-Mateeva, R Schaefer, D Froster, U G Caldes, T de la Hoya, M McGuffog, L Antoniou, A C Nevanlinna, H Radice, P Benítez, J |
| author_facet | Osorio, A Milne, R L Pita, G Peterlongo, P Heikkinen, T Simard, J Chenevix-Trench, G Spurdle, A B Beesley, J Chen, X Healey, S Neuhausen, S L Ding, Y C Couch, F J Wang, X Lindor, N Manoukian, S Barile, M Viel, A Tizzoni, L Szabo, C I Foretova, L Zikan, M Claes, K Greene, M H Mai, P Rennert, G Lejbkowicz, F Barnett-Griness, O Andrulis, I L Ozcelik, H Weerasooriya, N Gerdes, A-M Thomassen, M Cruger, D G Caligo, M A Friedman, E Kaufman, B Laitman, Y Cohen, S Kontorovich, T Gershoni-Baruch, R Dagan, E Jernström, H Askmalm, M S Arver, B Malmer, B Domchek, S M Nathanson, K L Brunet, J Ramón y Cajal, T Yannoukakos, D Hamann, U Hogervorst, F B L Verhoef, S García, EB Gómez Wijnen, J T van den Ouweland, A Easton, D F Peock, S Cook, M Oliver, C T Frost, D Luccarini, C Evans, D G Lalloo, F Eeles, R Pichert, G Cook, J Hodgson, S Morrison, P J Douglas, F Godwin, A K Sinilnikova, O M Barjhoux, L Stoppa-Lyonnet, D Moncoutier, V Giraud, S Cassini, C Olivier-Faivre, L Révillion, F Peyrat, J-P Muller, D Fricker, J-P Lynch, H T John, E M Buys, S Daly, M Hopper, J L Terry, M B Miron, A Yassin, Y Goldgar, D Singer, C F Gschwantler-Kaulich, D Pfeiler, G Spiess, A-C Hansen, Thomas v O Johannsson, O T Kirchhoff, T Offit, K Kosarin, K Piedmonte, M Rodriguez, G C Wakeley, K Boggess, J F Basil, J Schwartz, P E Blank, S V Toland, A E Montagna, M Casella, C Imyanitov, E N Allavena, A Schmutzler, R K Versmold, B Engel, C Meindl, A Ditsch, N Arnold, N Niederacher, D Deißler, H Fiebig, B Varon-Mateeva, R Schaefer, D Froster, U G Caldes, T de la Hoya, M McGuffog, L Antoniou, A C Nevanlinna, H Radice, P Benítez, J |
| author_sort | Osorio, A |
| collection | PubMed |
| description | BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. METHODS: We have genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach. RESULTS: We found no evidence of association with breast cancer risk for BRCA1 (per-allele HR: 0.98, 95% CI: 0.93–1.04, P=0.5) or BRCA2 (per-allele HR: 0.97, 95% CI: 0.89–1.06, P=0.5) mutation carriers. CONCLUSION: This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out. |
| format | Text |
| id | pubmed-2795432 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27954322010-12-14 Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) Osorio, A Milne, R L Pita, G Peterlongo, P Heikkinen, T Simard, J Chenevix-Trench, G Spurdle, A B Beesley, J Chen, X Healey, S Neuhausen, S L Ding, Y C Couch, F J Wang, X Lindor, N Manoukian, S Barile, M Viel, A Tizzoni, L Szabo, C I Foretova, L Zikan, M Claes, K Greene, M H Mai, P Rennert, G Lejbkowicz, F Barnett-Griness, O Andrulis, I L Ozcelik, H Weerasooriya, N Gerdes, A-M Thomassen, M Cruger, D G Caligo, M A Friedman, E Kaufman, B Laitman, Y Cohen, S Kontorovich, T Gershoni-Baruch, R Dagan, E Jernström, H Askmalm, M S Arver, B Malmer, B Domchek, S M Nathanson, K L Brunet, J Ramón y Cajal, T Yannoukakos, D Hamann, U Hogervorst, F B L Verhoef, S García, EB Gómez Wijnen, J T van den Ouweland, A Easton, D F Peock, S Cook, M Oliver, C T Frost, D Luccarini, C Evans, D G Lalloo, F Eeles, R Pichert, G Cook, J Hodgson, S Morrison, P J Douglas, F Godwin, A K Sinilnikova, O M Barjhoux, L Stoppa-Lyonnet, D Moncoutier, V Giraud, S Cassini, C Olivier-Faivre, L Révillion, F Peyrat, J-P Muller, D Fricker, J-P Lynch, H T John, E M Buys, S Daly, M Hopper, J L Terry, M B Miron, A Yassin, Y Goldgar, D Singer, C F Gschwantler-Kaulich, D Pfeiler, G Spiess, A-C Hansen, Thomas v O Johannsson, O T Kirchhoff, T Offit, K Kosarin, K Piedmonte, M Rodriguez, G C Wakeley, K Boggess, J F Basil, J Schwartz, P E Blank, S V Toland, A E Montagna, M Casella, C Imyanitov, E N Allavena, A Schmutzler, R K Versmold, B Engel, C Meindl, A Ditsch, N Arnold, N Niederacher, D Deißler, H Fiebig, B Varon-Mateeva, R Schaefer, D Froster, U G Caldes, T de la Hoya, M McGuffog, L Antoniou, A C Nevanlinna, H Radice, P Benítez, J Br J Cancer Genetics and Genomics BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. METHODS: We have genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach. RESULTS: We found no evidence of association with breast cancer risk for BRCA1 (per-allele HR: 0.98, 95% CI: 0.93–1.04, P=0.5) or BRCA2 (per-allele HR: 0.97, 95% CI: 0.89–1.06, P=0.5) mutation carriers. CONCLUSION: This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out. Nature Publishing Group 2009-12-15 2009-11-17 /pmc/articles/PMC2795432/ /pubmed/19920816 http://dx.doi.org/10.1038/sj.bjc.6605416 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Genetics and Genomics Osorio, A Milne, R L Pita, G Peterlongo, P Heikkinen, T Simard, J Chenevix-Trench, G Spurdle, A B Beesley, J Chen, X Healey, S Neuhausen, S L Ding, Y C Couch, F J Wang, X Lindor, N Manoukian, S Barile, M Viel, A Tizzoni, L Szabo, C I Foretova, L Zikan, M Claes, K Greene, M H Mai, P Rennert, G Lejbkowicz, F Barnett-Griness, O Andrulis, I L Ozcelik, H Weerasooriya, N Gerdes, A-M Thomassen, M Cruger, D G Caligo, M A Friedman, E Kaufman, B Laitman, Y Cohen, S Kontorovich, T Gershoni-Baruch, R Dagan, E Jernström, H Askmalm, M S Arver, B Malmer, B Domchek, S M Nathanson, K L Brunet, J Ramón y Cajal, T Yannoukakos, D Hamann, U Hogervorst, F B L Verhoef, S García, EB Gómez Wijnen, J T van den Ouweland, A Easton, D F Peock, S Cook, M Oliver, C T Frost, D Luccarini, C Evans, D G Lalloo, F Eeles, R Pichert, G Cook, J Hodgson, S Morrison, P J Douglas, F Godwin, A K Sinilnikova, O M Barjhoux, L Stoppa-Lyonnet, D Moncoutier, V Giraud, S Cassini, C Olivier-Faivre, L Révillion, F Peyrat, J-P Muller, D Fricker, J-P Lynch, H T John, E M Buys, S Daly, M Hopper, J L Terry, M B Miron, A Yassin, Y Goldgar, D Singer, C F Gschwantler-Kaulich, D Pfeiler, G Spiess, A-C Hansen, Thomas v O Johannsson, O T Kirchhoff, T Offit, K Kosarin, K Piedmonte, M Rodriguez, G C Wakeley, K Boggess, J F Basil, J Schwartz, P E Blank, S V Toland, A E Montagna, M Casella, C Imyanitov, E N Allavena, A Schmutzler, R K Versmold, B Engel, C Meindl, A Ditsch, N Arnold, N Niederacher, D Deißler, H Fiebig, B Varon-Mateeva, R Schaefer, D Froster, U G Caldes, T de la Hoya, M McGuffog, L Antoniou, A C Nevanlinna, H Radice, P Benítez, J Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) |
| title | Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) |
| title_full | Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) |
| title_fullStr | Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) |
| title_full_unstemmed | Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) |
| title_short | Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) |
| title_sort | evaluation of a candidate breast cancer associated snp in ercc4 as a risk modifier in brca1 and brca2 mutation carriers. results from the consortium of investigators of modifiers of brca1/brca2 (cimba) |
| topic | Genetics and Genomics |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795432/ https://www.ncbi.nlm.nih.gov/pubmed/19920816 http://dx.doi.org/10.1038/sj.bjc.6605416 |
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evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT oliverct evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT frostd evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT luccarinic evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT evansdg evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT lalloof evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT eelesr evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT pichertg evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT cookj evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT hodgsons evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT morrisonpj evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT douglasf evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT godwinak evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT sinilnikovaom evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT barjhouxl evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT stoppalyonnetd evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT moncoutierv evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT girauds evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT cassinic evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT olivierfaivrel evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT revillionf evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT peyratjp evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT mullerd evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT frickerjp evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT lynchht evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT johnem evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT buyss evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT dalym evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT hopperjl evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT terrymb evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT mirona evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT yassiny evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT goldgard evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT singercf evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT gschwantlerkaulichd evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT pfeilerg evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT spiessac evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT hansenthomasvo evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT johannssonot evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT kirchhofft evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT offitk evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT kosarink evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT piedmontem evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT rodriguezgc evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT wakeleyk evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT boggessjf evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT basilj evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT schwartzpe evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT blanksv evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT tolandae evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT montagnam evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT casellac evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT imyanitoven evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT allavenaa evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT schmutzlerrk evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT versmoldb evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT engelc evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT meindla evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT ditschn evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT arnoldn evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT niederacherd evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT deißlerh evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT fiebigb evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT varonmateevar evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT schaeferd evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT frosterug evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT caldest evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT delahoyam evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT mcguffogl evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT antoniouac evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT nevanlinnah evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT radicep evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba AT benitezj evaluationofacandidatebreastcancerassociatedsnpinercc4asariskmodifierinbrca1andbrca2mutationcarriersresultsfromtheconsortiumofinvestigatorsofmodifiersofbrca1brca2cimba |