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Applications of genome-scale metabolic reconstructions
The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-t...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795471/ https://www.ncbi.nlm.nih.gov/pubmed/19888215 http://dx.doi.org/10.1038/msb.2009.77 |
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author | Oberhardt, Matthew A Palsson, Bernhard Ø Papin, Jason A |
author_facet | Oberhardt, Matthew A Palsson, Bernhard Ø Papin, Jason A |
author_sort | Oberhardt, Matthew A |
collection | PubMed |
description | The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology. |
format | Text |
id | pubmed-2795471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-27954712009-12-18 Applications of genome-scale metabolic reconstructions Oberhardt, Matthew A Palsson, Bernhard Ø Papin, Jason A Mol Syst Biol Review Article The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology. Nature Publishing Group 2009-11-03 /pmc/articles/PMC2795471/ /pubmed/19888215 http://dx.doi.org/10.1038/msb.2009.77 Text en Copyright © 2009, EMBO and Nature Publishing Group http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. |
spellingShingle | Review Article Oberhardt, Matthew A Palsson, Bernhard Ø Papin, Jason A Applications of genome-scale metabolic reconstructions |
title | Applications of genome-scale metabolic reconstructions |
title_full | Applications of genome-scale metabolic reconstructions |
title_fullStr | Applications of genome-scale metabolic reconstructions |
title_full_unstemmed | Applications of genome-scale metabolic reconstructions |
title_short | Applications of genome-scale metabolic reconstructions |
title_sort | applications of genome-scale metabolic reconstructions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795471/ https://www.ncbi.nlm.nih.gov/pubmed/19888215 http://dx.doi.org/10.1038/msb.2009.77 |
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