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Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex

Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) activity at multiple sites within the cortex of awake monkeys and organotyp...

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Detalles Bibliográficos
Autores principales: Thiagarajan, Tara C., Lebedev, Mikhail A., Nicolelis, Miguel A., Plenz, Dietmar
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795777/
https://www.ncbi.nlm.nih.gov/pubmed/20084093
http://dx.doi.org/10.1371/journal.pbio.1000278
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author Thiagarajan, Tara C.
Lebedev, Mikhail A.
Nicolelis, Miguel A.
Plenz, Dietmar
author_facet Thiagarajan, Tara C.
Lebedev, Mikhail A.
Nicolelis, Miguel A.
Plenz, Dietmar
author_sort Thiagarajan, Tara C.
collection PubMed
description Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) activity at multiple sites within the cortex of awake monkeys and organotypic cultures of cortex. We show that when the composite activity of a local neuronal group exceeds a threshold, its activity pattern, as reflected in the LFP, occurs without distortion at other cortex sites via fast synaptic transmission. These large-amplitude LFPs, which we call coherence potentials, extend up to hundreds of milliseconds and mark periods of loss-less spread of temporal and amplitude information much like action potentials at the single-cell level. However, coherence potentials have an additional degree of freedom in the diversity of their waveforms, which provides a high-dimensional parameter for encoding information and allows identification of particular associations. Such nonlinear behavior is analogous to the spread of ideas and behaviors in social networks.
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spelling pubmed-27957772010-01-16 Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex Thiagarajan, Tara C. Lebedev, Mikhail A. Nicolelis, Miguel A. Plenz, Dietmar PLoS Biol Research Article Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) activity at multiple sites within the cortex of awake monkeys and organotypic cultures of cortex. We show that when the composite activity of a local neuronal group exceeds a threshold, its activity pattern, as reflected in the LFP, occurs without distortion at other cortex sites via fast synaptic transmission. These large-amplitude LFPs, which we call coherence potentials, extend up to hundreds of milliseconds and mark periods of loss-less spread of temporal and amplitude information much like action potentials at the single-cell level. However, coherence potentials have an additional degree of freedom in the diversity of their waveforms, which provides a high-dimensional parameter for encoding information and allows identification of particular associations. Such nonlinear behavior is analogous to the spread of ideas and behaviors in social networks. Public Library of Science 2010-01-12 /pmc/articles/PMC2795777/ /pubmed/20084093 http://dx.doi.org/10.1371/journal.pbio.1000278 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Thiagarajan, Tara C.
Lebedev, Mikhail A.
Nicolelis, Miguel A.
Plenz, Dietmar
Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex
title Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex
title_full Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex
title_fullStr Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex
title_full_unstemmed Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex
title_short Coherence Potentials: Loss-Less, All-or-None Network Events in the Cortex
title_sort coherence potentials: loss-less, all-or-none network events in the cortex
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795777/
https://www.ncbi.nlm.nih.gov/pubmed/20084093
http://dx.doi.org/10.1371/journal.pbio.1000278
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