Cargando…

Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort

In order to evaluate the population impact of putative causal genetic variants over the life course of disease, we extended the static estimation of population-attributable risk fraction and developed a novel tool to evaluate how the population impact changes over time using the Framingham Heart Stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Yu, Hu, Yijuan, North, Kari E, Franceschini, Nora, Lin, Danyu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795890/
https://www.ncbi.nlm.nih.gov/pubmed/20017983
_version_ 1782175463367507968
author Yan, Yu
Hu, Yijuan
North, Kari E
Franceschini, Nora
Lin, Danyu
author_facet Yan, Yu
Hu, Yijuan
North, Kari E
Franceschini, Nora
Lin, Danyu
author_sort Yan, Yu
collection PubMed
description In order to evaluate the population impact of putative causal genetic variants over the life course of disease, we extended the static estimation of population-attributable risk fraction and developed a novel tool to evaluate how the population impact changes over time using the Framingham Heart Study Offspring Cohort data provided to the Genetic Analysis Workshop 16, Problem 2. A set of population-attributable risk fractions based on survival functions were estimated under the proportional hazards models. The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level.
format Text
id pubmed-2795890
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27958902009-12-18 Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort Yan, Yu Hu, Yijuan North, Kari E Franceschini, Nora Lin, Danyu BMC Proc Proceedings In order to evaluate the population impact of putative causal genetic variants over the life course of disease, we extended the static estimation of population-attributable risk fraction and developed a novel tool to evaluate how the population impact changes over time using the Framingham Heart Study Offspring Cohort data provided to the Genetic Analysis Workshop 16, Problem 2. A set of population-attributable risk fractions based on survival functions were estimated under the proportional hazards models. The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level. BioMed Central 2009-12-15 /pmc/articles/PMC2795890/ /pubmed/20017983 Text en Copyright ©2009 Yan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Yan, Yu
Hu, Yijuan
North, Kari E
Franceschini, Nora
Lin, Danyu
Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
title Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
title_full Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
title_fullStr Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
title_full_unstemmed Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
title_short Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
title_sort evaluation of population impact of candidate polymorphisms for coronary heart disease in the framingham heart study offspring cohort
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795890/
https://www.ncbi.nlm.nih.gov/pubmed/20017983
work_keys_str_mv AT yanyu evaluationofpopulationimpactofcandidatepolymorphismsforcoronaryheartdiseaseintheframinghamheartstudyoffspringcohort
AT huyijuan evaluationofpopulationimpactofcandidatepolymorphismsforcoronaryheartdiseaseintheframinghamheartstudyoffspringcohort
AT northkarie evaluationofpopulationimpactofcandidatepolymorphismsforcoronaryheartdiseaseintheframinghamheartstudyoffspringcohort
AT franceschininora evaluationofpopulationimpactofcandidatepolymorphismsforcoronaryheartdiseaseintheframinghamheartstudyoffspringcohort
AT lindanyu evaluationofpopulationimpactofcandidatepolymorphismsforcoronaryheartdiseaseintheframinghamheartstudyoffspringcohort