Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1

The genes PTPN22 and HLA-DRB1 have been found by a number of studies to confer an increased risk for rheumatoid arthritis (RA), which indicates that both genes play an important role in RA etiology. It is believed that they not only have strong association with RA individually, but also interact wit...

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Autores principales: Qiao, Bo, Huang, Chien Hsun, Cong, Lei, Xie, Jun, Lo, Shaw-Hwa, Zheng, Tian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795906/
https://www.ncbi.nlm.nih.gov/pubmed/20017999
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author Qiao, Bo
Huang, Chien Hsun
Cong, Lei
Xie, Jun
Lo, Shaw-Hwa
Zheng, Tian
author_facet Qiao, Bo
Huang, Chien Hsun
Cong, Lei
Xie, Jun
Lo, Shaw-Hwa
Zheng, Tian
author_sort Qiao, Bo
collection PubMed
description The genes PTPN22 and HLA-DRB1 have been found by a number of studies to confer an increased risk for rheumatoid arthritis (RA), which indicates that both genes play an important role in RA etiology. It is believed that they not only have strong association with RA individually, but also interact with other related genes that have not been found to have predisposing RA mutations. In this paper, we conduct genome-wide searches for RA-associated gene-gene interactions that involve PTPN22 or HLA-DRB1 using the Genetic Analysis Workshop 16 Problem 1 data from the North American Rheumatoid Arthritis Consortium. MGC13017, HSPCAL3, MIA, PTPNS1L, and IGLVI-70, which showed association with RA in previous studies, have been confirmed in our analysis.
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spelling pubmed-27959062009-12-18 Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1 Qiao, Bo Huang, Chien Hsun Cong, Lei Xie, Jun Lo, Shaw-Hwa Zheng, Tian BMC Proc Proceedings The genes PTPN22 and HLA-DRB1 have been found by a number of studies to confer an increased risk for rheumatoid arthritis (RA), which indicates that both genes play an important role in RA etiology. It is believed that they not only have strong association with RA individually, but also interact with other related genes that have not been found to have predisposing RA mutations. In this paper, we conduct genome-wide searches for RA-associated gene-gene interactions that involve PTPN22 or HLA-DRB1 using the Genetic Analysis Workshop 16 Problem 1 data from the North American Rheumatoid Arthritis Consortium. MGC13017, HSPCAL3, MIA, PTPNS1L, and IGLVI-70, which showed association with RA in previous studies, have been confirmed in our analysis. BioMed Central 2009-12-15 /pmc/articles/PMC2795906/ /pubmed/20017999 Text en Copyright ©2009 Qiao et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Qiao, Bo
Huang, Chien Hsun
Cong, Lei
Xie, Jun
Lo, Shaw-Hwa
Zheng, Tian
Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
title Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
title_full Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
title_fullStr Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
title_full_unstemmed Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
title_short Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
title_sort genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with ptpn22 and hla-drb1
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795906/
https://www.ncbi.nlm.nih.gov/pubmed/20017999
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