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Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1

With the rapid development of large-scale high-throughput genotyping technology, genome-wide association studies have become a popular approach to mapping genes underlying common human disorders. Some genes are discovered, but many more have not been. Because these genes were not initially identifie...

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Detalles Bibliográficos
Autores principales: Xiao, Xiangjun, Zhang, Yufang, Wang, Kai
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795908/
https://www.ncbi.nlm.nih.gov/pubmed/20018001
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author Xiao, Xiangjun
Zhang, Yufang
Wang, Kai
author_facet Xiao, Xiangjun
Zhang, Yufang
Wang, Kai
author_sort Xiao, Xiangjun
collection PubMed
description With the rapid development of large-scale high-throughput genotyping technology, genome-wide association studies have become a popular approach to mapping genes underlying common human disorders. Some genes are discovered, but many more have not been. Because these genes were not initially identified, it is reasonable to assume that their main effect is weak. We propose a method to accommodate such a situation. It is applied to the Genetic Analysis Workshop 16 Problem 1 case-control data in which shared-epitope alleles of HLA-DRB1 show very strong association with rheumatoid arthritis. Because some previous functional studies have reported association of gene KCNB1 to rheumatoid arthritis, we evaluate whether the gene KCNB1 contributes to the genetics of rheumatoid arthritis in this data set. Fifteen single-nucleotide polymorphisms from this gene were chosen. The association of KCNB1 gene to rheumatoid arthritis seems to be moderate.
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spelling pubmed-27959082009-12-18 Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1 Xiao, Xiangjun Zhang, Yufang Wang, Kai BMC Proc Proceedings With the rapid development of large-scale high-throughput genotyping technology, genome-wide association studies have become a popular approach to mapping genes underlying common human disorders. Some genes are discovered, but many more have not been. Because these genes were not initially identified, it is reasonable to assume that their main effect is weak. We propose a method to accommodate such a situation. It is applied to the Genetic Analysis Workshop 16 Problem 1 case-control data in which shared-epitope alleles of HLA-DRB1 show very strong association with rheumatoid arthritis. Because some previous functional studies have reported association of gene KCNB1 to rheumatoid arthritis, we evaluate whether the gene KCNB1 contributes to the genetics of rheumatoid arthritis in this data set. Fifteen single-nucleotide polymorphisms from this gene were chosen. The association of KCNB1 gene to rheumatoid arthritis seems to be moderate. BioMed Central 2009-12-15 /pmc/articles/PMC2795908/ /pubmed/20018001 Text en Copyright ©2009 Xiao et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Xiao, Xiangjun
Zhang, Yufang
Wang, Kai
Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
title Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
title_full Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
title_fullStr Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
title_full_unstemmed Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
title_short Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
title_sort association of kcnb1 to rheumatoid arthritis via interaction with hla-drb1
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795908/
https://www.ncbi.nlm.nih.gov/pubmed/20018001
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