Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study

Cardiovascular diseases are associated with combinations of phenotypic traits, which are in turn caused by a combination of environmental and genetic factors. Because of the diversity of pathways that may lead to cardiovascular diseases, we examined the so-called intermediate phenotypes, which are o...

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Detalles Bibliográficos
Autores principales: Waaijenborg, Sandra, Zwinderman, Aeilko H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795946/
https://www.ncbi.nlm.nih.gov/pubmed/20018039
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author Waaijenborg, Sandra
Zwinderman, Aeilko H
author_facet Waaijenborg, Sandra
Zwinderman, Aeilko H
author_sort Waaijenborg, Sandra
collection PubMed
description Cardiovascular diseases are associated with combinations of phenotypic traits, which are in turn caused by a combination of environmental and genetic factors. Because of the diversity of pathways that may lead to cardiovascular diseases, we examined the so-called intermediate phenotypes, which are often repeatedly measured. We developed a penalized nonlinear canonical correlation analysis to associate multiple repeatedly measured traits with high-dimensional single-nucleotide polymorphism data.
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spelling pubmed-27959462009-12-18 Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study Waaijenborg, Sandra Zwinderman, Aeilko H BMC Proc Proceedings Cardiovascular diseases are associated with combinations of phenotypic traits, which are in turn caused by a combination of environmental and genetic factors. Because of the diversity of pathways that may lead to cardiovascular diseases, we examined the so-called intermediate phenotypes, which are often repeatedly measured. We developed a penalized nonlinear canonical correlation analysis to associate multiple repeatedly measured traits with high-dimensional single-nucleotide polymorphism data. BioMed Central 2009-12-15 /pmc/articles/PMC2795946/ /pubmed/20018039 Text en Copyright ©2009 Waaijenborg and Zwinderman; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Waaijenborg, Sandra
Zwinderman, Aeilko H
Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study
title Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study
title_full Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study
title_fullStr Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study
title_full_unstemmed Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study
title_short Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study
title_sort associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the framingham heart study
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795946/
https://www.ncbi.nlm.nih.gov/pubmed/20018039
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