Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach

We applied a penalized regression approach to single-nucleotide polymorphisms in regions on chromosomes 1, 6, and 9 of the North American Rheumatoid Arthritis Consortium data. Results were compared with a standard single-locus association test. Overall, the penalized regression approach did not appe...

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Detalles Bibliográficos
Autores principales: Croiseau, Pascal, Cordell, Heather J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795962/
https://www.ncbi.nlm.nih.gov/pubmed/20018055
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author Croiseau, Pascal
Cordell, Heather J
author_facet Croiseau, Pascal
Cordell, Heather J
author_sort Croiseau, Pascal
collection PubMed
description We applied a penalized regression approach to single-nucleotide polymorphisms in regions on chromosomes 1, 6, and 9 of the North American Rheumatoid Arthritis Consortium data. Results were compared with a standard single-locus association test. Overall, the penalized regression approach did not appear to offer any advantage with respect to either detection or localization of disease-associated polymorphisms, compared with the single-locus approach.
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spelling pubmed-27959622009-12-18 Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach Croiseau, Pascal Cordell, Heather J BMC Proc Proceedings We applied a penalized regression approach to single-nucleotide polymorphisms in regions on chromosomes 1, 6, and 9 of the North American Rheumatoid Arthritis Consortium data. Results were compared with a standard single-locus association test. Overall, the penalized regression approach did not appear to offer any advantage with respect to either detection or localization of disease-associated polymorphisms, compared with the single-locus approach. BioMed Central 2009-12-15 /pmc/articles/PMC2795962/ /pubmed/20018055 Text en Copyright ©2009 Croiseau and Cordell; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Croiseau, Pascal
Cordell, Heather J
Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach
title Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach
title_full Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach
title_fullStr Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach
title_full_unstemmed Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach
title_short Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach
title_sort analysis of north american rheumatoid arthritis consortium data using a penalized logistic regression approach
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795962/
https://www.ncbi.nlm.nih.gov/pubmed/20018055
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