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No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia
OBJECTIVE: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hyp...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Korean Neuropsychiatric Association
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796045/ https://www.ncbi.nlm.nih.gov/pubmed/20046383 http://dx.doi.org/10.4306/pi.2009.6.2.108 |
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author | Lee, Heon-Jeong Kang, Seung-Gul Choi, Jung-Eun Park, Young-Min Lim, Se-Won Rhee, Min Kyu Kim, Seung-Hyun Kim, Leen |
author_facet | Lee, Heon-Jeong Kang, Seung-Gul Choi, Jung-Eun Park, Young-Min Lim, Se-Won Rhee, Min Kyu Kim, Seung-Hyun Kim, Leen |
author_sort | Lee, Heon-Jeong |
collection | PubMed |
description | OBJECTIVE: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. METHODS: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. RESULTS: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. CONCLUSION: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD. |
format | Text |
id | pubmed-2796045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-27960452009-12-30 No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia Lee, Heon-Jeong Kang, Seung-Gul Choi, Jung-Eun Park, Young-Min Lim, Se-Won Rhee, Min Kyu Kim, Seung-Hyun Kim, Leen Psychiatry Investig Original Article OBJECTIVE: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. METHODS: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. RESULTS: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. CONCLUSION: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD. Korean Neuropsychiatric Association 2009-06 2009-06-30 /pmc/articles/PMC2796045/ /pubmed/20046383 http://dx.doi.org/10.4306/pi.2009.6.2.108 Text en Copyright © 2009 Official Journal of Korean Neuropsychiatric Association http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Heon-Jeong Kang, Seung-Gul Choi, Jung-Eun Park, Young-Min Lim, Se-Won Rhee, Min Kyu Kim, Seung-Hyun Kim, Leen No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia |
title | No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia |
title_full | No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia |
title_fullStr | No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia |
title_full_unstemmed | No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia |
title_short | No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia |
title_sort | no evidence for association between tyrosine hydroxylase gene val81met polymorphism and susceptibility to tardive dyskinesia in schizophrenia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796045/ https://www.ncbi.nlm.nih.gov/pubmed/20046383 http://dx.doi.org/10.4306/pi.2009.6.2.108 |
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