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Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease
Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily d...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Korean Neuropsychiatric Association
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796072/ https://www.ncbi.nlm.nih.gov/pubmed/20046400 http://dx.doi.org/10.4306/pi.2009.6.3.226 |
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author | Sunwoo, Young-Kyung Lee, Jeong-Seop Kim, Won-Hyoung Shin, Yong-Bum Lee, Myung-Ji Cho, In-Hee Ock, Sun-Myeong |
author_facet | Sunwoo, Young-Kyung Lee, Jeong-Seop Kim, Won-Hyoung Shin, Yong-Bum Lee, Myung-Ji Cho, In-Hee Ock, Sun-Myeong |
author_sort | Sunwoo, Young-Kyung |
collection | PubMed |
description | Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily depression and mental deterioration. However, psychosis has rarely been reported as a major symptom of HSD. We report two siblings who presented psychiatric symptoms as major clinical presentations, accompanied by ataxic and spastic gait, dysarthria, and typical neuroimaging findings of HSD. A 14-year-old girl presented complex motor tics, stereotypic behavior and anxiety symptoms. Her older brother, a 16-year-old boy, presented prominent auditory hallucinations, persecutory delusions and social withdrawal symptoms. Psychiatric symptoms were improved after atypical antipsychotic treatment. HSD is a rare disease but should be carefully considered in the diagnosis of patients with both motor disorder and various psychiatric symptoms. |
format | Text |
id | pubmed-2796072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-27960722009-12-30 Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease Sunwoo, Young-Kyung Lee, Jeong-Seop Kim, Won-Hyoung Shin, Yong-Bum Lee, Myung-Ji Cho, In-Hee Ock, Sun-Myeong Psychiatry Investig Case Report Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily depression and mental deterioration. However, psychosis has rarely been reported as a major symptom of HSD. We report two siblings who presented psychiatric symptoms as major clinical presentations, accompanied by ataxic and spastic gait, dysarthria, and typical neuroimaging findings of HSD. A 14-year-old girl presented complex motor tics, stereotypic behavior and anxiety symptoms. Her older brother, a 16-year-old boy, presented prominent auditory hallucinations, persecutory delusions and social withdrawal symptoms. Psychiatric symptoms were improved after atypical antipsychotic treatment. HSD is a rare disease but should be carefully considered in the diagnosis of patients with both motor disorder and various psychiatric symptoms. Korean Neuropsychiatric Association 2009-09 2009-08-03 /pmc/articles/PMC2796072/ /pubmed/20046400 http://dx.doi.org/10.4306/pi.2009.6.3.226 Text en Copyright © 2009 Official Journal of Korean Neuropsychiatric Association http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sunwoo, Young-Kyung Lee, Jeong-Seop Kim, Won-Hyoung Shin, Yong-Bum Lee, Myung-Ji Cho, In-Hee Ock, Sun-Myeong Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease |
title | Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease |
title_full | Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease |
title_fullStr | Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease |
title_full_unstemmed | Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease |
title_short | Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease |
title_sort | psychiatric disorder in two siblings with hallervorden-spatz disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796072/ https://www.ncbi.nlm.nih.gov/pubmed/20046400 http://dx.doi.org/10.4306/pi.2009.6.3.226 |
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