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An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis
OBJECTIVE: Recent molecular and genetic investigations have suggested that the current nosology for major psychiatric disorders, based on the "two-entities-principal" is not accurate with respect to clinical observations; patient groups that do not fit to the current operative diagnostic b...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Korean Neuropsychiatric Association
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796087/ https://www.ncbi.nlm.nih.gov/pubmed/20046407 http://dx.doi.org/10.4306/pi.2008.5.1.41 |
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author | Kawashige, Seiya Kanazawa, Tetsufumi Tsutsumi, Atsushi Kikuyama, Hiroki Uenishi, Hiroyuki Koh, Jun Yoneda, Hiroshi |
author_facet | Kawashige, Seiya Kanazawa, Tetsufumi Tsutsumi, Atsushi Kikuyama, Hiroki Uenishi, Hiroyuki Koh, Jun Yoneda, Hiroshi |
author_sort | Kawashige, Seiya |
collection | PubMed |
description | OBJECTIVE: Recent molecular and genetic investigations have suggested that the current nosology for major psychiatric disorders, based on the "two-entities-principal" is not accurate with respect to clinical observations; patient groups that do not fit to the current operative diagnostic boundaries are readily identified. We aimed to perform an investigation of the signal transducer and activator of transcription 6 (STAT6) gene (located on 12q13), which has an important role in the apoptotic cascade, with patients suffering from periodic psychosis. METHODS: Genetic association study has been employed for the current work. Investigated six tag-SNPs were chosen from Hapmap database. RESULTS: Among six tag-SNPs, one marker (rs10783813), located in the STAT6 gene, showed modest association (p<0.05), although no marker or haplotype block showed association after Bonferroni's correction. CONCLUSION: Future studies will reveal the etiological role of STAT6, and of other genes of the apoptotic cascade, in major psychiatric disorders. |
format | Text |
id | pubmed-2796087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-27960872009-12-30 An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis Kawashige, Seiya Kanazawa, Tetsufumi Tsutsumi, Atsushi Kikuyama, Hiroki Uenishi, Hiroyuki Koh, Jun Yoneda, Hiroshi Psychiatry Investig Original Article OBJECTIVE: Recent molecular and genetic investigations have suggested that the current nosology for major psychiatric disorders, based on the "two-entities-principal" is not accurate with respect to clinical observations; patient groups that do not fit to the current operative diagnostic boundaries are readily identified. We aimed to perform an investigation of the signal transducer and activator of transcription 6 (STAT6) gene (located on 12q13), which has an important role in the apoptotic cascade, with patients suffering from periodic psychosis. METHODS: Genetic association study has been employed for the current work. Investigated six tag-SNPs were chosen from Hapmap database. RESULTS: Among six tag-SNPs, one marker (rs10783813), located in the STAT6 gene, showed modest association (p<0.05), although no marker or haplotype block showed association after Bonferroni's correction. CONCLUSION: Future studies will reveal the etiological role of STAT6, and of other genes of the apoptotic cascade, in major psychiatric disorders. Korean Neuropsychiatric Association 2008-03 2008-03-31 /pmc/articles/PMC2796087/ /pubmed/20046407 http://dx.doi.org/10.4306/pi.2008.5.1.41 Text en Copyright © 2008 Official Journal of Korean Neuropsychiatric Association http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kawashige, Seiya Kanazawa, Tetsufumi Tsutsumi, Atsushi Kikuyama, Hiroki Uenishi, Hiroyuki Koh, Jun Yoneda, Hiroshi An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis |
title | An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis |
title_full | An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis |
title_fullStr | An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis |
title_full_unstemmed | An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis |
title_short | An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis |
title_sort | association study of the signal transducer and activator of transcription 6 gene with periodic psychosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796087/ https://www.ncbi.nlm.nih.gov/pubmed/20046407 http://dx.doi.org/10.4306/pi.2008.5.1.41 |
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