Differential Impact of Tumor Suppressor Pathways on DNA Damage Response and Therapy-Induced Transformation in a Mouse Primary Cell Model

The RB and p53 tumor suppressors are mediators of DNA damage response, and compound inactivation of RB and p53 is a common occurrence in human cancers. Surprisingly, their cooperation in DNA damage signaling in relation to tumorigenesis and therapeutic response remains enigmatic. In the context of i...

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Detalles Bibliográficos
Autores principales: McClendon, A. Kathleen, Dean, Jeffry L., Ertel, Adam, Knudsen, Erik S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796719/
https://www.ncbi.nlm.nih.gov/pubmed/20049321
http://dx.doi.org/10.1371/journal.pone.0008558

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