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Targeted interrogation of copy number variation using SCIMMkit

Summary: Copy number variants (CNVs) contribute substantially to human genomic diversity, and development of accurate and efficient methods for CNV genotyping is a central problem in exploring human genotype–phenotype associations. SCIMMkit provides a robust, integrated implementation of three previ...

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Detalles Bibliográficos
Autores principales: Zerr, Troy, Cooper, Gregory M., Eichler, Evan E., Nickerson, Deborah A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796813/
https://www.ncbi.nlm.nih.gov/pubmed/19846438
http://dx.doi.org/10.1093/bioinformatics/btp606
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author Zerr, Troy
Cooper, Gregory M.
Eichler, Evan E.
Nickerson, Deborah A.
author_facet Zerr, Troy
Cooper, Gregory M.
Eichler, Evan E.
Nickerson, Deborah A.
author_sort Zerr, Troy
collection PubMed
description Summary: Copy number variants (CNVs) contribute substantially to human genomic diversity, and development of accurate and efficient methods for CNV genotyping is a central problem in exploring human genotype–phenotype associations. SCIMMkit provides a robust, integrated implementation of three previously validated algorithms [SCIMM (SNP-Conditional Mixture Modeling), SCIMM-Search and SCOUT (SNP-Conditional OUTlier detection)] for targeted interrogation of CNVs using Illumina Infinium II and GoldenGate SNP assays. SCIMMkit is applicable to standardized genome-wide SNP arrays and customized multiplexed SNP panels, providing economy, efficiency and flexibility in experimental design. Availability: Source code and documentation are available for noncommercial use at http://droog.gs.washington.edu/scimmkit. Contact: troyz@u.washington.edu Supplementary information: Supplementary data are available at Bioinformatics online.
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spelling pubmed-27968132009-12-23 Targeted interrogation of copy number variation using SCIMMkit Zerr, Troy Cooper, Gregory M. Eichler, Evan E. Nickerson, Deborah A. Bioinformatics Applications Note Summary: Copy number variants (CNVs) contribute substantially to human genomic diversity, and development of accurate and efficient methods for CNV genotyping is a central problem in exploring human genotype–phenotype associations. SCIMMkit provides a robust, integrated implementation of three previously validated algorithms [SCIMM (SNP-Conditional Mixture Modeling), SCIMM-Search and SCOUT (SNP-Conditional OUTlier detection)] for targeted interrogation of CNVs using Illumina Infinium II and GoldenGate SNP assays. SCIMMkit is applicable to standardized genome-wide SNP arrays and customized multiplexed SNP panels, providing economy, efficiency and flexibility in experimental design. Availability: Source code and documentation are available for noncommercial use at http://droog.gs.washington.edu/scimmkit. Contact: troyz@u.washington.edu Supplementary information: Supplementary data are available at Bioinformatics online. Oxford University Press 2010-01-01 2009-10-21 /pmc/articles/PMC2796813/ /pubmed/19846438 http://dx.doi.org/10.1093/bioinformatics/btp606 Text en © The Author(s) 2009. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Note
Zerr, Troy
Cooper, Gregory M.
Eichler, Evan E.
Nickerson, Deborah A.
Targeted interrogation of copy number variation using SCIMMkit
title Targeted interrogation of copy number variation using SCIMMkit
title_full Targeted interrogation of copy number variation using SCIMMkit
title_fullStr Targeted interrogation of copy number variation using SCIMMkit
title_full_unstemmed Targeted interrogation of copy number variation using SCIMMkit
title_short Targeted interrogation of copy number variation using SCIMMkit
title_sort targeted interrogation of copy number variation using scimmkit
topic Applications Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796813/
https://www.ncbi.nlm.nih.gov/pubmed/19846438
http://dx.doi.org/10.1093/bioinformatics/btp606
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