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Reward Networks in the Brain as Captured by Connectivity Measures

An assortment of human behaviors is thought to be driven by rewards including reinforcement learning, novelty processing, learning, decision making, economic choice, incentive motivation, and addiction. In each case the ventral tegmental area/ventral striatum (nucleus accumbens) (VTA–VS) system has...

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Detalles Bibliográficos
Autores principales: Camara, Estela, Rodriguez-Fornells, Antoni, Ye, Zheng, Münte, Thomas F.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796919/
https://www.ncbi.nlm.nih.gov/pubmed/20198152
http://dx.doi.org/10.3389/neuro.01.034.2009
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author Camara, Estela
Rodriguez-Fornells, Antoni
Ye, Zheng
Münte, Thomas F.
author_facet Camara, Estela
Rodriguez-Fornells, Antoni
Ye, Zheng
Münte, Thomas F.
author_sort Camara, Estela
collection PubMed
description An assortment of human behaviors is thought to be driven by rewards including reinforcement learning, novelty processing, learning, decision making, economic choice, incentive motivation, and addiction. In each case the ventral tegmental area/ventral striatum (nucleus accumbens) (VTA–VS) system has been implicated as a key structure by functional imaging studies, mostly on the basis of standard, univariate analyses. Here we propose that standard functional magnetic resonance imaging analysis needs to be complemented by methods that take into account the differential connectivity of the VTA–VS system in the different behavioral contexts in order to describe reward based processes more appropriately. We first consider the wider network for reward processing as it emerged from animal experimentation. Subsequently, an example for a method to assess functional connectivity is given. Finally, we illustrate the usefulness of such analyses by examples regarding reward valuation, reward expectation and the role of reward in addiction.
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spelling pubmed-27969192010-03-02 Reward Networks in the Brain as Captured by Connectivity Measures Camara, Estela Rodriguez-Fornells, Antoni Ye, Zheng Münte, Thomas F. Front Neurosci Neuroscience An assortment of human behaviors is thought to be driven by rewards including reinforcement learning, novelty processing, learning, decision making, economic choice, incentive motivation, and addiction. In each case the ventral tegmental area/ventral striatum (nucleus accumbens) (VTA–VS) system has been implicated as a key structure by functional imaging studies, mostly on the basis of standard, univariate analyses. Here we propose that standard functional magnetic resonance imaging analysis needs to be complemented by methods that take into account the differential connectivity of the VTA–VS system in the different behavioral contexts in order to describe reward based processes more appropriately. We first consider the wider network for reward processing as it emerged from animal experimentation. Subsequently, an example for a method to assess functional connectivity is given. Finally, we illustrate the usefulness of such analyses by examples regarding reward valuation, reward expectation and the role of reward in addiction. Frontiers Research Foundation 2009-12-15 /pmc/articles/PMC2796919/ /pubmed/20198152 http://dx.doi.org/10.3389/neuro.01.034.2009 Text en Copyright © 2009 Camara, Rodriguez-Fornells, Ye and Münte. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Camara, Estela
Rodriguez-Fornells, Antoni
Ye, Zheng
Münte, Thomas F.
Reward Networks in the Brain as Captured by Connectivity Measures
title Reward Networks in the Brain as Captured by Connectivity Measures
title_full Reward Networks in the Brain as Captured by Connectivity Measures
title_fullStr Reward Networks in the Brain as Captured by Connectivity Measures
title_full_unstemmed Reward Networks in the Brain as Captured by Connectivity Measures
title_short Reward Networks in the Brain as Captured by Connectivity Measures
title_sort reward networks in the brain as captured by connectivity measures
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796919/
https://www.ncbi.nlm.nih.gov/pubmed/20198152
http://dx.doi.org/10.3389/neuro.01.034.2009
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