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Pharmacokinetics and tissue distribution of PGG–paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts

PURPOSE: PGG–PTX is a water-soluble formulation of paclitaxel (PTX), made by conjugating PTX to poly(l-γ-glutamylglutamine) acid (PGG) via ester bonds, that spontaneously forms a nanoparticle in aqueous environments. The purpose of this study was to compare the pharmacokinetics and tissue distributi...

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Detalles Bibliográficos
Autores principales:	Wang, Xinghe, Zhao, Gang, Van, Sang, Jiang, Nan, Yu, Lei, Vera, David, Howell, Stephen B.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797414/ https://www.ncbi.nlm.nih.gov/pubmed/19593566 http://dx.doi.org/10.1007/s00280-009-1058-x

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