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Effect of rifampin on the pharmacokinetics of Axitinib (AG-013736) in Japanese and Caucasian healthy volunteers

PURPOSE: Axitinib, a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2, 3, is metabolized by cytochrome P450 3A4 and glucuronidation. This study evaluated the effect of rifampin, a potent inducer of drug-metabolizing enzymes, on axitinib plasma pharmacokinetics. Equ...

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Detalles Bibliográficos
Autores principales:	Pithavala, Y. K., Tortorici, M., Toh, M., Garrett, M., Hee, B., Kuruganti, U., Ni, G., Klamerus, K. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797436/ https://www.ncbi.nlm.nih.gov/pubmed/19603168 http://dx.doi.org/10.1007/s00280-009-1065-y

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