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Inhibition of SOC/Ca(2+)/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
BACKGROUND: Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, has been proposed as a treatment for pulmonary arterial hypertension (PAH). The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells (PASMC) is unclear. Nuclear translocation of nuclear factor o...
Autores principales: | Wang, Cong, Li, Ji-Feng, Zhao, Lan, Liu, Jie, Wan, Jun, Wang, Yue Xiu, Wang, Jun, Wang, Chen |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797778/ https://www.ncbi.nlm.nih.gov/pubmed/20003325 http://dx.doi.org/10.1186/1465-9921-10-123 |
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