Cargando…

Inhibition of SOC/Ca(2+)/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells

BACKGROUND: Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, has been proposed as a treatment for pulmonary arterial hypertension (PAH). The mechanism of its anti-proliferative effect on pulmonary artery smooth muscle cells (PASMC) is unclear. Nuclear translocation of nuclear factor o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Cong, Li, Ji-Feng, Zhao, Lan, Liu, Jie, Wan, Jun, Wang, Yue Xiu, Wang, Jun, Wang, Chen
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797778/ https://www.ncbi.nlm.nih.gov/pubmed/20003325 http://dx.doi.org/10.1186/1465-9921-10-123

Ejemplares similares

Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells
por: Li, Shaojun, et al.
Publicado: (2017)

Silencing of STIM1 attenuates hypoxia-induced PASMCs proliferation via inhibition of the SOC/Ca(2+)/NFAT pathway
por: Hou, Xianhua, et al.
Publicado: (2013)

Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous
por: Perros, Frédéric, et al.
Publicado: (2019)

Arterial Wall Stress Controls NFAT5 Activity in Vascular Smooth Muscle Cells
por: Scherer, Clemens, et al.
Publicado: (2014)

MiR-223/NFAT5 signaling suppresses arterial smooth muscle cell proliferation and motility in vitro
por: Su, Feifei, et al.
Publicado: (2020)

The maintenance ability and Ca(2+) availability of skeletal muscle are enhanced by sildenafil
por: Huang, Mei, et al.
Publicado: (2016)

NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells
por: Zappe, Maren, et al.
Publicado: (2018)

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells
por: Rodriguez, Marisela, et al.
Publicado: (2021)

MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis
por: Zhou, Ting, et al.
Publicado: (2021)

CDK5/NFAT5-Regulated Transporters Involved in Osmoregulation in Fejervarya cancrivora
por: Li, Jiao, et al.
Publicado: (2022)

Mesenchymal stem cells suppress CaN/NFAT expression in the pulmonary arteries of rats with pulmonary hypertension
por: LIU, JUNFENG, et al.
Publicado: (2015)

Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice
por: Hirakata, Saki, et al.
Publicado: (2020)

Deletion of Socs3 Expression in Aortic Smooth Muscle Cells Ameliorates Aortic Dissection
por: Murphy, Michael P., et al.
Publicado: (2020)

Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells
por: Growcott, Ellena J, et al.
Publicado: (2006)

TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells
por: Hödebeck, Maren, et al.
Publicado: (2014)

Age Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate
por: Lee, Sophie N., et al.
Publicado: (2017)

Sildenafil in the treatment of pulmonary hypertension
por: Barnett, Christopher F, et al.
Publicado: (2006)

An Age-Wise Comparison of Human Airway Smooth Muscle Proliferative Capacity
por: Fayon, Michael, et al.
Publicado: (2015)

Proliferative Pathways of Vascular Smooth Muscle Cells in Response to Intermittent Hypoxia
por: Kyotani, Yoji, et al.
Publicado: (2019)

The Roles of Ca(2+)/NFAT Signaling Genes in Kawasaki Disease: Single- and Multiple-Risk Genetic Variants
por: Wang, Wei, et al.
Publicado: (2014)

NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells
por: Laban, Hebatullah, et al.
Publicado: (2021)

The role of Ca(2+)/Calcineurin/NFAT signalling pathway in osteoblastogenesis
por: Ren, Ranyue, et al.
Publicado: (2021)

Intracellular Ca release in skinned smooth muscle
Publicado: (1982)

Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil‐Bosentan and Sildenafil‐Ambrisentan Combination Therapies for Pulmonary Hypertension
por: Hakamata, A, et al.
Publicado: (2016)

Prognostic value of members of NFAT family for pan-cancer and a prediction model based on NFAT2 in bladder cancer
por: Dai, Zhou-Tong, et al.
Publicado: (2021)

Sildenafil in pediatric pulmonary arterial hypertension
por: Dhariwal, AK, et al.
Publicado: (2015)

Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype
por: Pera, Tonio, et al.
Publicado: (2010)

Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia
por: Okolo, Frances C., et al.
Publicado: (2018)

Relative expression of hormone receptors by endothelial and smooth muscle cells in proliferative and non-proliferative areas of congenital arteriovenous malformations
por: Utami, A. M., et al.
Publicado: (2023)

Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells
por: Zhao, Jian-Zhi, et al.
Publicado: (2022)

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca(2+) Signals
por: Kar, Pulak, et al.
Publicado: (2016)

Role of BK(Ca) in Stretch-Induced Relaxation of Colonic Smooth Muscle
por: Ren, Jie, et al.
Publicado: (2016)

The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes
por: Chu, Yu-Wen, et al.
Publicado: (2017)

Novel Mechanisms of Sildenafil in Pulmonary Hypertension Involving Cytokines/Chemokines, MAP Kinases and Akt
por: Kiss, Tamas, et al.
Publicado: (2014)

Effects of sildenafil and/or muscle derived stem cells on myocardial infarction
por: Wang, Judy SC, et al.
Publicado: (2012)

Chronic Hypoxia Increases TRPC6 Expression and Basal Intracellular Ca(2+) Concentration in Rat Distal Pulmonary Venous Smooth Muscle
por: Xu, Lei, et al.
Publicado: (2014)

Analysis of lncRNA-miRNA-mRNA Interactions in Hyper-proliferative Human Pulmonary Arterial Smooth Muscle Cells
por: Chinnappan, Mahendran, et al.
Publicado: (2019)

miR‐137 and its target T‐type Ca(V)3.1 channel modulate dedifferentiation and proliferation of cerebrovascular smooth muscle cells in simulated microgravity rats by regulating calcineurin/NFAT pathway
por: Zhang, Bin, et al.
Publicado: (2020)

Focal Ca(2+) Transient Detection in Smooth Muscle
por: Young, John S., et al.
Publicado: (2009)

Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells
por: Hwang, Sun Mi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gg1eirk1ahdb6f5n1gnjg14u0m