Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

OBJECTIVE: Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass– and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(−/−) mice are lean and Fto(+/−) mice are resistant to diet-induced obesity. We aimed to determine whether FTO mutations are dispropor...

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Detalles Bibliográficos
Autores principales: Meyre, David, Proulx, Karine, Kawagoe-Takaki, Hiroko, Vatin, Vincent, Gutiérrez-Aguilar, Ruth, Lyon, Debbie, Ma, Marcella, Choquet, Helene, Horber, Fritz, Van Hul, Wim, Van Gaal, Luc, Balkau, Beverley, Visvikis-Siest, Sophie, Pattou, François, Farooqi, I. Sadaf, Saudek, Vladimir, O'Rahilly, Stephen, Froguel, Philippe, Sedgwick, Barbara, Yeo, Giles S.H.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797938/
https://www.ncbi.nlm.nih.gov/pubmed/19833892
http://dx.doi.org/10.2337/db09-0703

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