Cargando…

Randomized Placebo-Controlled Double-Blind Clinical Trial of Cannabis-Based Medicinal Product (Sativex) in Painful Diabetic Neuropathy: Depression is a major confounding factor

OBJECTIVE: To assess the efficacy of Sativex, a cannabis-based medicinal extract, as adjuvant treatment in painful diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS: In this randomized controlled trial, 30 subjects with painful DPN received daily Sativex or placebo. The primary outco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Selvarajah, Dinesh, Gandhi, Rajiv, Emery, Celia J., Tesfaye, Solomon
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797957/ https://www.ncbi.nlm.nih.gov/pubmed/19808912 http://dx.doi.org/10.2337/dc09-1029

Ejemplares similares

Painful Diabetic Neuropathy Is Associated With Greater Autonomic Dysfunction Than Painless Diabetic Neuropathy
por: Gandhi, Rajiv A., et al.
Publicado: (2010)

Painful and Painless Diabetic Neuropathies: What Is the Difference?
por: Shillo, Pallai, et al.
Publicado: (2019)

Assessment of blinding to treatment allocation in studies of a cannabis-based medicine (Sativex®) in people with multiple sclerosis: a new approach
por: Wright, Stephen, et al.
Publicado: (2012)

Preservation of thalamic neuronal function may be a prerequisite for pain perception in diabetic neuropathy: A magnetic resonance spectroscopy study
por: Gandhi, Rajiv, et al.
Publicado: (2023)

SUDOSCAN: A Simple, Rapid, and Objective Method with Potential for Screening for Diabetic Peripheral Neuropathy
por: Selvarajah, Dinesh, et al.
Publicado: (2015)

Large-Fiber Dysfunction in Diabetic Peripheral Neuropathy Is Predicted by Cardiovascular Risk Factors
por: Elliott, Jackie, et al.
Publicado: (2009)

Deep Learning Classification of Treatment Response in Diabetic Painful Neuropathy: A Combined Machine Learning and Magnetic Resonance Neuroimaging Methodological Study
por: Teh, Kevin, et al.
Publicado: (2022)

Imbalanced learning: Improving classification of diabetic neuropathy from magnetic resonance imaging
por: Teh, Kevin, et al.
Publicado: (2020)

Microvascular Perfusion Abnormalities of the Thalamus in Painful but Not Painless Diabetic Polyneuropathy: A clue to the pathogenesis of pain in type 1 diabetes
por: Selvarajah, Dinesh, et al.
Publicado: (2011)

Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial
por: Didangelos, Triantafyllos, et al.
Publicado: (2021)

Sativex-induced neurobehavioral effects: causal or concausal? A practical advice!
por: Russo, Margherita, et al.
Publicado: (2015)

Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
por: Russo, Margherita, et al.
Publicado: (2015)

Double-blind, placebo-controlled study of HGF gene therapy in diabetic neuropathy
por: Kessler, John A, et al.
Publicado: (2015)

Nerve and Vascular Biomarkers in Skin Biopsies Differentiate Painful From Painless Peripheral Neuropathy in Type 2 Diabetes
por: Shillo, Pallai, et al.
Publicado: (2021)

The role of Sativex in robotic rehabilitation in individuals with multiple sclerosis: Rationale, study design, and methodology
por: Russo, Margherita, et al.
Publicado: (2017)

Pharmacokinetics of Sativex(®) in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders
por: Fernández-Trapero, María, et al.
Publicado: (2020)

Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy
por: Teh, Kevin, et al.
Publicado: (2021)

The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy
por: Themistocleous, Andreas C., et al.
Publicado: (2016)

Sativex® (nabiximols) cannabinoid oromucosal spray in patients with resistant multiple sclerosis spasticity: the Belgian experience
por: D’hooghe, Marie, et al.
Publicado: (2021)

Central Pain Processing in Chronic Chemotherapy-Induced Peripheral Neuropathy: A Functional Magnetic Resonance Imaging Study
por: Boland, Elaine G., et al.
Publicado: (2014)

Cannabis-Based Medicine for Neuropathic Pain and Spasticity—A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial
por: Hansen, Julie Schjødtz, et al.
Publicado: (2023)

Randomized double-blind, placebo-controlled study of oral gabapentin for prevention of neuropathy in patients receiving paclitaxel
por: Pandey, Praful, et al.
Publicado: (2023)

Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: A randomised, double-blind, placebo-controlled study in cannabis users
por: Hindocha, Chandni, et al.
Publicado: (2015)

Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial
por: Selvarajah, Dinesh, et al.
Publicado: (2018)

The acute effects of cannabis with and without cannabidiol in adults and adolescents: A randomised, double‐blind, placebo‐controlled, crossover experiment
por: Lawn, Will, et al.
Publicado: (2023)

Major Potential Confounder Not Addressed
por: Vines, Jennifer
Publicado: (2006)

Effects of Semelil (ANGIPARS™) on diabetic peripheral neuropathy: A randomized, double-blind Placebo-controlled clinical trial
por: Bakhshayeshi, S., et al.
Publicado: (2011)

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Vilazodone in Adolescents with Major Depressive Disorder
por: Durgam, Suresh, et al.
Publicado: (2018)

Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
por: Chaves, Carolina, et al.
Publicado: (2020)

Cannabidiol-enriched cannabis extraction product in Parkinson’s disease: A randomized, double-blind, and placebo-controlled trial in Buriram Hospital
por: Kanjanarangsichai, Auempa, et al.
Publicado: (2022)

A novel method for controlling unobserved confounding using double confounders
por: Liu, Lu, et al.
Publicado: (2020)

Analgesic effect of duloxetine compared to nortryptiline in patients with painful neuropathy: A randomized, double-blind, placebo-controlled trial
por: Mohammadali Bayani, Mohammadali, et al.
Publicado: (2021)

Sativex in resistant multiple sclerosis spasticity: Discontinuation study in a large population of Italian patients (SA.FE. study)
por: Messina, Silvia, et al.
Publicado: (2017)

Efficacy of levomilnacipran extended-release in major depressive disorder: pooled analysis of 5 double-blind, placebo-controlled trials
por: Montgomery, Stuart A., et al.
Publicado: (2014)

Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression
por: Laferton, Johannes A. C., et al.
Publicado: (2018)

Relapse prevention in adults with major depressive disorder treated with vilazodone: a randomized, double-blind, placebo-controlled trial
por: Durgam, Suresh, et al.
Publicado: (2018)

Efficacy of adjunctive low-dose cariprazine in major depressive disorder: a randomized, double-blind, placebo-controlled trial
por: Fava, Maurizio, et al.
Publicado: (2018)

Randomized, double‐blind, placebo‐controlled study to assess the efficacy and safety of vortioxetine in Japanese patients with major depressive disorder
por: Inoue, Takeshi, et al.
Publicado: (2019)

Efficacy of Gemfibrozil as an Adjunct to Sertraline in Major Depressive Disorder, A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial
por: Zandifar, Atefeh, et al.
Publicado: (2021)

Frequency-modulated electromagnetic neural stimulation (FREMS) as a treatment for symptomatic diabetic neuropathy: results from a double-blind, randomised, multicentre, long-term, placebo-controlled clinical trial
por: Bosi, E., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2o17obhqr6s0k7j6ir9fgm6o8i