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The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer

Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effect...

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Detalles Bibliográficos
Autores principales: Gien, Lilian T., Mackay, Helen J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798102/
https://www.ncbi.nlm.nih.gov/pubmed/20049345
http://dx.doi.org/10.1155/2010/151750
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author Gien, Lilian T.
Mackay, Helen J.
author_facet Gien, Lilian T.
Mackay, Helen J.
author_sort Gien, Lilian T.
collection PubMed
description Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effective against tumors which have lost homologous recombination (HR) through loss of functional BRCA1 and BRCA2. PARP inhibitors potentially represent a major breakthrough for patients with hereditary BRCA-associated cancers. Furthermore their role in sporadic epithelial ovarian cancer is emerging with identification of additional subpopulations of women who may benefit a priority. This paper will summarize the mechanism of action of PARP inhibition and its role in the treatment of BRCA1- and 2-associated cancers. We will then expand on the broader relevance and future directions for PARP inhibition in the clinical setting.
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spelling pubmed-27981022010-01-04 The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer Gien, Lilian T. Mackay, Helen J. J Oncol Review Article Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effective against tumors which have lost homologous recombination (HR) through loss of functional BRCA1 and BRCA2. PARP inhibitors potentially represent a major breakthrough for patients with hereditary BRCA-associated cancers. Furthermore their role in sporadic epithelial ovarian cancer is emerging with identification of additional subpopulations of women who may benefit a priority. This paper will summarize the mechanism of action of PARP inhibition and its role in the treatment of BRCA1- and 2-associated cancers. We will then expand on the broader relevance and future directions for PARP inhibition in the clinical setting. Hindawi Publishing Corporation 2010 2009-12-16 /pmc/articles/PMC2798102/ /pubmed/20049345 http://dx.doi.org/10.1155/2010/151750 Text en Copyright © 2010 L. T. Gien and H. J. Mackay. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gien, Lilian T.
Mackay, Helen J.
The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
title The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
title_full The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
title_fullStr The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
title_full_unstemmed The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
title_short The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
title_sort emerging role of parp inhibitors in the treatment of epithelial ovarian cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798102/
https://www.ncbi.nlm.nih.gov/pubmed/20049345
http://dx.doi.org/10.1155/2010/151750
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