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The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effect...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798102/ https://www.ncbi.nlm.nih.gov/pubmed/20049345 http://dx.doi.org/10.1155/2010/151750 |
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author | Gien, Lilian T. Mackay, Helen J. |
author_facet | Gien, Lilian T. Mackay, Helen J. |
author_sort | Gien, Lilian T. |
collection | PubMed |
description | Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effective against tumors which have lost homologous recombination (HR) through loss of functional BRCA1 and BRCA2. PARP inhibitors potentially represent a major breakthrough for patients with hereditary BRCA-associated cancers. Furthermore their role in sporadic epithelial ovarian cancer is emerging with identification of additional subpopulations of women who may benefit a priority. This paper will summarize the mechanism of action of PARP inhibition and its role in the treatment of BRCA1- and 2-associated cancers. We will then expand on the broader relevance and future directions for PARP inhibition in the clinical setting. |
format | Text |
id | pubmed-2798102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27981022010-01-04 The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer Gien, Lilian T. Mackay, Helen J. J Oncol Review Article Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effective against tumors which have lost homologous recombination (HR) through loss of functional BRCA1 and BRCA2. PARP inhibitors potentially represent a major breakthrough for patients with hereditary BRCA-associated cancers. Furthermore their role in sporadic epithelial ovarian cancer is emerging with identification of additional subpopulations of women who may benefit a priority. This paper will summarize the mechanism of action of PARP inhibition and its role in the treatment of BRCA1- and 2-associated cancers. We will then expand on the broader relevance and future directions for PARP inhibition in the clinical setting. Hindawi Publishing Corporation 2010 2009-12-16 /pmc/articles/PMC2798102/ /pubmed/20049345 http://dx.doi.org/10.1155/2010/151750 Text en Copyright © 2010 L. T. Gien and H. J. Mackay. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gien, Lilian T. Mackay, Helen J. The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer |
title | The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer |
title_full | The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer |
title_fullStr | The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer |
title_full_unstemmed | The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer |
title_short | The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer |
title_sort | emerging role of parp inhibitors in the treatment of epithelial ovarian cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798102/ https://www.ncbi.nlm.nih.gov/pubmed/20049345 http://dx.doi.org/10.1155/2010/151750 |
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