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Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor

Cushing syndrome is rare in infancy and usually due to an adrenocortical tumor (ACT). We report an infant with Cushing syndrome due to adrenocortical carcinoma. The patient presented at six months of age with a three-month history of growth failure, rapid weight gain, acne, and irritability. Physica...

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Autores principales: Fudge, Elizabeth B., von Allmen, Daniel, Volmar, Keith E., Calikoglu, Ali S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798106/
https://www.ncbi.nlm.nih.gov/pubmed/20049152
http://dx.doi.org/10.1155/2009/168749
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author Fudge, Elizabeth B.
von Allmen, Daniel
Volmar, Keith E.
Calikoglu, Ali S.
author_facet Fudge, Elizabeth B.
von Allmen, Daniel
Volmar, Keith E.
Calikoglu, Ali S.
author_sort Fudge, Elizabeth B.
collection PubMed
description Cushing syndrome is rare in infancy and usually due to an adrenocortical tumor (ACT). We report an infant with Cushing syndrome due to adrenocortical carcinoma. The patient presented at six months of age with a three-month history of growth failure, rapid weight gain, acne, and irritability. Physical examination showed obesity, hypertension, and Cushingoid features. Biochemical evaluation showed very high serum cortisol, mildly elevated testosterone, and suppressed ACTH. Abdominal MRI revealed a heterogeneous right adrenal mass extending into the inferior vena cava. Evaluation for metastases was negative. The tumor was removed surgically en bloc. Pathologic examination demonstrated low mitotic rate, but capsular and vascular invasion. She received no adjuvant therapy. Her linear growth has improved and Cushingoid features resolved. Hormonal markers and quarterly PET scans have been negative for recurrence 24 months postoperatively. In conclusion, adrenocortical neoplasms in children are rare, but should be considered in the differential diagnosis of Cushing syndrome.
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spelling pubmed-27981062010-01-04 Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor Fudge, Elizabeth B. von Allmen, Daniel Volmar, Keith E. Calikoglu, Ali S. Int J Pediatr Endocrinol Case Report Cushing syndrome is rare in infancy and usually due to an adrenocortical tumor (ACT). We report an infant with Cushing syndrome due to adrenocortical carcinoma. The patient presented at six months of age with a three-month history of growth failure, rapid weight gain, acne, and irritability. Physical examination showed obesity, hypertension, and Cushingoid features. Biochemical evaluation showed very high serum cortisol, mildly elevated testosterone, and suppressed ACTH. Abdominal MRI revealed a heterogeneous right adrenal mass extending into the inferior vena cava. Evaluation for metastases was negative. The tumor was removed surgically en bloc. Pathologic examination demonstrated low mitotic rate, but capsular and vascular invasion. She received no adjuvant therapy. Her linear growth has improved and Cushingoid features resolved. Hormonal markers and quarterly PET scans have been negative for recurrence 24 months postoperatively. In conclusion, adrenocortical neoplasms in children are rare, but should be considered in the differential diagnosis of Cushing syndrome. Hindawi Publishing Corporation 2009 2009-11-24 /pmc/articles/PMC2798106/ /pubmed/20049152 http://dx.doi.org/10.1155/2009/168749 Text en Copyright © 2009 Elizabeth B. Fudge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fudge, Elizabeth B.
von Allmen, Daniel
Volmar, Keith E.
Calikoglu, Ali S.
Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor
title Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor
title_full Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor
title_fullStr Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor
title_full_unstemmed Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor
title_short Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor
title_sort cushing syndrome in a 6-month-old infant due to adrenocortical tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798106/
https://www.ncbi.nlm.nih.gov/pubmed/20049152
http://dx.doi.org/10.1155/2009/168749
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