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Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer
The eukaryotic translation initiation factor eIF4E is elevated in about 30% of human malignancies including HNSCC where its levels correlate with poor prognosis. Here, we discuss the biochemical and molecular underpinnings of the oncogenic potential of eIF4E. Studies in human leukemia specimens, and...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798714/ https://www.ncbi.nlm.nih.gov/pubmed/20049173 http://dx.doi.org/10.1155/2009/981679 |