Hyperhemolysis in a patient with β-thalassemia major

A case of hyperhemolysis in a 2-year-old boy with β thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a na...

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Detalles Bibliográficos
Autores principales: Morawakage, Lakmali R., Perera, B. J. C., Dias, P. D. N., Wijewardana, S. K.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798775/
https://www.ncbi.nlm.nih.gov/pubmed/20041094
http://dx.doi.org/10.4103/0973-6247.45259
Descripción
Sumario:A case of hyperhemolysis in a 2-year-old boy with β thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a narrow thermal range). Because there was no significant improvement with steroid and immunoglobulin infusions, cyclophosphamide therapy was tried with notable success.

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