Hyperhemolysis in a patient with β-thalassemia major

A case of hyperhemolysis in a 2-year-old boy with β thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a na...

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Autores principales: Morawakage, Lakmali R., Perera, B. J. C., Dias, P. D. N., Wijewardana, S. K.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798775/
https://www.ncbi.nlm.nih.gov/pubmed/20041094
http://dx.doi.org/10.4103/0973-6247.45259
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author Morawakage, Lakmali R.
Perera, B. J. C.
Dias, P. D. N.
Wijewardana, S. K.
author_facet Morawakage, Lakmali R.
Perera, B. J. C.
Dias, P. D. N.
Wijewardana, S. K.
author_sort Morawakage, Lakmali R.
collection PubMed
description A case of hyperhemolysis in a 2-year-old boy with β thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a narrow thermal range). Because there was no significant improvement with steroid and immunoglobulin infusions, cyclophosphamide therapy was tried with notable success.
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spelling pubmed-27987752009-12-29 Hyperhemolysis in a patient with β-thalassemia major Morawakage, Lakmali R. Perera, B. J. C. Dias, P. D. N. Wijewardana, S. K. Asian J Transfus Sci Case Report A case of hyperhemolysis in a 2-year-old boy with β thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a narrow thermal range). Because there was no significant improvement with steroid and immunoglobulin infusions, cyclophosphamide therapy was tried with notable success. Medknow Publications Pvt Ltd 2009-01 /pmc/articles/PMC2798775/ /pubmed/20041094 http://dx.doi.org/10.4103/0973-6247.45259 Text en © Asian Journal of Transfusion Science http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Morawakage, Lakmali R.
Perera, B. J. C.
Dias, P. D. N.
Wijewardana, S. K.
Hyperhemolysis in a patient with β-thalassemia major
title Hyperhemolysis in a patient with β-thalassemia major
title_full Hyperhemolysis in a patient with β-thalassemia major
title_fullStr Hyperhemolysis in a patient with β-thalassemia major
title_full_unstemmed Hyperhemolysis in a patient with β-thalassemia major
title_short Hyperhemolysis in a patient with β-thalassemia major
title_sort hyperhemolysis in a patient with β-thalassemia major
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798775/
https://www.ncbi.nlm.nih.gov/pubmed/20041094
http://dx.doi.org/10.4103/0973-6247.45259
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AT pererabjc hyperhemolysisinapatientwithbthalassemiamajor
AT diaspdn hyperhemolysisinapatientwithbthalassemiamajor
AT wijewardanask hyperhemolysisinapatientwithbthalassemiamajor

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