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Bile acids in treatment of ocular disease

Bear bile has been included in Asian pharmacopeias for thousands of years in treatment of several diseases, ranging from sore throat to hemorrhoids. The hydrophilic bile acids tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) are the major bile acids of bear bile. Both of these are a...

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Detalles Bibliográficos
Autores principales: Boatright, Jeffrey H., Nickerson, John M., Moring, Anisha G., Pardue, Machelle T.
Formato: Texto
Lenguaje:English
Publicado: Humana Press Inc 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798994/
https://www.ncbi.nlm.nih.gov/pubmed/20046852
http://dx.doi.org/10.1007/s12177-009-9030-x
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author Boatright, Jeffrey H.
Nickerson, John M.
Moring, Anisha G.
Pardue, Machelle T.
author_facet Boatright, Jeffrey H.
Nickerson, John M.
Moring, Anisha G.
Pardue, Machelle T.
author_sort Boatright, Jeffrey H.
collection PubMed
description Bear bile has been included in Asian pharmacopeias for thousands of years in treatment of several diseases, ranging from sore throat to hemorrhoids. The hydrophilic bile acids tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) are the major bile acids of bear bile. Both of these are available as synthetic formulations and are approved by the health administrations of several countries for treatment of cirrhosis and gallstones. This review briefly covers the use of bear bile in Traditional Chinese Medicine, bile acid physiology, approved use of UDCA and TUDCA in Western medicine, and recent research exploring their neuroprotective properties, including in models of ocular disease.
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spelling pubmed-27989942009-12-30 Bile acids in treatment of ocular disease Boatright, Jeffrey H. Nickerson, John M. Moring, Anisha G. Pardue, Machelle T. J Ocul Biol Dis Infor Article Bear bile has been included in Asian pharmacopeias for thousands of years in treatment of several diseases, ranging from sore throat to hemorrhoids. The hydrophilic bile acids tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) are the major bile acids of bear bile. Both of these are available as synthetic formulations and are approved by the health administrations of several countries for treatment of cirrhosis and gallstones. This review briefly covers the use of bear bile in Traditional Chinese Medicine, bile acid physiology, approved use of UDCA and TUDCA in Western medicine, and recent research exploring their neuroprotective properties, including in models of ocular disease. Humana Press Inc 2009-08-27 /pmc/articles/PMC2798994/ /pubmed/20046852 http://dx.doi.org/10.1007/s12177-009-9030-x Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Boatright, Jeffrey H.
Nickerson, John M.
Moring, Anisha G.
Pardue, Machelle T.
Bile acids in treatment of ocular disease
title Bile acids in treatment of ocular disease
title_full Bile acids in treatment of ocular disease
title_fullStr Bile acids in treatment of ocular disease
title_full_unstemmed Bile acids in treatment of ocular disease
title_short Bile acids in treatment of ocular disease
title_sort bile acids in treatment of ocular disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798994/
https://www.ncbi.nlm.nih.gov/pubmed/20046852
http://dx.doi.org/10.1007/s12177-009-9030-x
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