Defects in DNA Ligase I Trigger PCNA Ubiquitination at Lysine 107

In all eukaryotes, the ligation of newly synthesized DNA, also known as Okazaki fragments, is catalyzed by DNA ligase I1. An individual with a DNA ligase I deficiency exhibited growth retardation, sunlight sensitivity and severe immunosuppression2, likely due to accumulation of DNA damage. Surprisin...

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Detalles Bibliográficos
Autores principales: Das-Bradoo, Sapna, Nguyen, Hai Dang, Wood, Jamie L., Ricke, Robin M., Haworth, Justin C., Bielinsky, Anja-Katrin
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799194/
https://www.ncbi.nlm.nih.gov/pubmed/20010813
http://dx.doi.org/10.1038/ncb2007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799194/
https://www.ncbi.nlm.nih.gov/pubmed/20010813
http://dx.doi.org/10.1038/ncb2007

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