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The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology
OBJECTIVES: We introduce and describe the Breast Cancer and the Environment Research Centers (BCERC), a research network with a transdisciplinary approach to elucidating the role of environmental factors in pubertal development as a window on breast cancer etiology. We describe the organization of f...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799453/ https://www.ncbi.nlm.nih.gov/pubmed/20049199 http://dx.doi.org/10.1289/ehp.0800120 |
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author | Hiatt, Robert A. Haslam, Sandra Z. Osuch, Janet |
author_facet | Hiatt, Robert A. Haslam, Sandra Z. Osuch, Janet |
author_sort | Hiatt, Robert A. |
collection | PubMed |
description | OBJECTIVES: We introduce and describe the Breast Cancer and the Environment Research Centers (BCERC), a research network with a transdisciplinary approach to elucidating the role of environmental factors in pubertal development as a window on breast cancer etiology. We describe the organization of four national centers integrated into the BCERC network. DATA SOURCES: Investigators use a common conceptual framework based on multiple levels of biologic, behavioral, and social organization across the life span. The approach connects basic biologic studies with rodent models and tissue culture systems, a coordinated multicenter epidemiologic cohort study of prepubertal girls, and the integration of community members of breast cancer advocates as key members of the research team to comprise the network. DATA EXTRACTION: Relevant literature is reviewed that describes current knowledge across levels of organization. Individual research questions and hypotheses in BCERC are driven by gaps in our knowledge that are presented at genetic, metabolic, cellular, individual, and environmental (physical and social) levels. DATA SYNTHESIS: As data collection on the cohort, animal experiments, and analyses proceed, results will be synthesized through a transdisciplinary approach. CONCLUSION: Center investigators are addressing a large number of specific research questions related to early pubertal onset, which is an established risk factor for breast cancer. BCERC research findings aimed at the primary prevention of breast cancer will be disseminated to the scientific community and to the public by breast cancer advocates, who have been integral members of the research process from its inception. |
format | Text |
id | pubmed-2799453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27994532010-01-04 The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology Hiatt, Robert A. Haslam, Sandra Z. Osuch, Janet Environ Health Perspect Review OBJECTIVES: We introduce and describe the Breast Cancer and the Environment Research Centers (BCERC), a research network with a transdisciplinary approach to elucidating the role of environmental factors in pubertal development as a window on breast cancer etiology. We describe the organization of four national centers integrated into the BCERC network. DATA SOURCES: Investigators use a common conceptual framework based on multiple levels of biologic, behavioral, and social organization across the life span. The approach connects basic biologic studies with rodent models and tissue culture systems, a coordinated multicenter epidemiologic cohort study of prepubertal girls, and the integration of community members of breast cancer advocates as key members of the research team to comprise the network. DATA EXTRACTION: Relevant literature is reviewed that describes current knowledge across levels of organization. Individual research questions and hypotheses in BCERC are driven by gaps in our knowledge that are presented at genetic, metabolic, cellular, individual, and environmental (physical and social) levels. DATA SYNTHESIS: As data collection on the cohort, animal experiments, and analyses proceed, results will be synthesized through a transdisciplinary approach. CONCLUSION: Center investigators are addressing a large number of specific research questions related to early pubertal onset, which is an established risk factor for breast cancer. BCERC research findings aimed at the primary prevention of breast cancer will be disseminated to the scientific community and to the public by breast cancer advocates, who have been integral members of the research process from its inception. National Institute of Environmental Health Sciences 2009-12 2009-06-16 /pmc/articles/PMC2799453/ /pubmed/20049199 http://dx.doi.org/10.1289/ehp.0800120 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Review Hiatt, Robert A. Haslam, Sandra Z. Osuch, Janet The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology |
title | The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology |
title_full | The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology |
title_fullStr | The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology |
title_full_unstemmed | The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology |
title_short | The Breast Cancer and the Environment Research Centers: Transdisciplinary Research on the Role of the Environment in Breast Cancer Etiology |
title_sort | breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799453/ https://www.ncbi.nlm.nih.gov/pubmed/20049199 http://dx.doi.org/10.1289/ehp.0800120 |
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