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Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)

BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS:...

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Autores principales: Castro-Giner, Francesc, Künzli, Nino, Jacquemin, Bénédicte, Forsberg, Bertil, de Cid, Rafael, Sunyer, Jordi, Jarvis, Deborah, Briggs, David, Vienneau, Danielle, Norback, Dan, González, Juan R., Guerra, Stefano, Janson, Christer, Antó, Josep-Maria, Wjst, Matthias, Heinrich, Joachim, Estivill, Xavier, Kogevinas, Manolis
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799467/
https://www.ncbi.nlm.nih.gov/pubmed/20049212
http://dx.doi.org/10.1289/ehp.0900589
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author Castro-Giner, Francesc
Künzli, Nino
Jacquemin, Bénédicte
Forsberg, Bertil
de Cid, Rafael
Sunyer, Jordi
Jarvis, Deborah
Briggs, David
Vienneau, Danielle
Norback, Dan
González, Juan R.
Guerra, Stefano
Janson, Christer
Antó, Josep-Maria
Wjst, Matthias
Heinrich, Joachim
Estivill, Xavier
Kogevinas, Manolis
author_facet Castro-Giner, Francesc
Künzli, Nino
Jacquemin, Bénédicte
Forsberg, Bertil
de Cid, Rafael
Sunyer, Jordi
Jarvis, Deborah
Briggs, David
Vienneau, Danielle
Norback, Dan
González, Juan R.
Guerra, Stefano
Janson, Christer
Antó, Josep-Maria
Wjst, Matthias
Heinrich, Joachim
Estivill, Xavier
Kogevinas, Manolis
author_sort Castro-Giner, Francesc
collection PubMed
description BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor α (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor β2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10–2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30–3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09–2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.
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spelling pubmed-27994672010-01-04 Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS) Castro-Giner, Francesc Künzli, Nino Jacquemin, Bénédicte Forsberg, Bertil de Cid, Rafael Sunyer, Jordi Jarvis, Deborah Briggs, David Vienneau, Danielle Norback, Dan González, Juan R. Guerra, Stefano Janson, Christer Antó, Josep-Maria Wjst, Matthias Heinrich, Joachim Estivill, Xavier Kogevinas, Manolis Environ Health Perspect Research BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor α (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor β2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10–2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30–3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09–2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma. National Institute of Environmental Health Sciences 2009-12 2009-07-23 /pmc/articles/PMC2799467/ /pubmed/20049212 http://dx.doi.org/10.1289/ehp.0900589 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Castro-Giner, Francesc
Künzli, Nino
Jacquemin, Bénédicte
Forsberg, Bertil
de Cid, Rafael
Sunyer, Jordi
Jarvis, Deborah
Briggs, David
Vienneau, Danielle
Norback, Dan
González, Juan R.
Guerra, Stefano
Janson, Christer
Antó, Josep-Maria
Wjst, Matthias
Heinrich, Joachim
Estivill, Xavier
Kogevinas, Manolis
Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
title Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
title_full Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
title_fullStr Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
title_full_unstemmed Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
title_short Traffic-Related Air Pollution, Oxidative Stress Genes, and Asthma (ECHRS)
title_sort traffic-related air pollution, oxidative stress genes, and asthma (echrs)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799467/
https://www.ncbi.nlm.nih.gov/pubmed/20049212
http://dx.doi.org/10.1289/ehp.0900589
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