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Prenatal Bisphenol A Exposure and Early Childhood Behavior

BACKGROUND: Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. OBJECTIVE: We examined the association between prenatal BPA exposure and behavior in 2-year-old children. METHODS: We used data from 249 mothers an...

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Detalles Bibliográficos
Autores principales: Braun, Joe M., Yolton, Kimberly, Dietrich, Kim N., Hornung, Richard, Ye, Xiaoyun, Calafat, Antonia M., Lanphear, Bruce P.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799471/
https://www.ncbi.nlm.nih.gov/pubmed/20049216
http://dx.doi.org/10.1289/ehp.0900979
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author Braun, Joe M.
Yolton, Kimberly
Dietrich, Kim N.
Hornung, Richard
Ye, Xiaoyun
Calafat, Antonia M.
Lanphear, Bruce P.
author_facet Braun, Joe M.
Yolton, Kimberly
Dietrich, Kim N.
Hornung, Richard
Ye, Xiaoyun
Calafat, Antonia M.
Lanphear, Bruce P.
author_sort Braun, Joe M.
collection PubMed
description BACKGROUND: Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. OBJECTIVE: We examined the association between prenatal BPA exposure and behavior in 2-year-old children. METHODS: We used data from 249 mothers and their children in Cincinnati, Ohio (USA). Maternal urine was collected around 16 and 26 weeks of gestation and at birth. BPA concentrations were quantified using high-performance liquid chromatography–isotope-dilution tandem mass spectrometry. Child behavior was assessed at 2 years of age using the second edition of the Behavioral Assessment System for Children (BASC-2). The association between prenatal BPA concentrations and BASC-2 scores was analyzed using linear regression. RESULTS: Median BPA concentrations were 1.8 (16 weeks), 1.7 (26 weeks), and 1.3 (birth) ng/mL. Mean (± SD) BASC-2 externalizing and internalizing scores were 47.6 ± 7.8 and 44.8 ± 7.0, respectively. After adjustment for confounders, log(10)-transformed mean prenatal BPA concentrations were associated with externalizing scores, but only among females [β = 6.0; 95% confidence interval (CI), 0.1–12.0]. Compared with 26-week and birth concentrations, BPA concentrations collected around 16 weeks were more strongly associated with externalizing scores among all children (β = 2.9; 95% CI, 0.2–5.7), and this association was stronger in females than in males. Among all children, measurements collected at ≤ 16 weeks showed a stronger association (β = 5.1; 95% CI, 1.5–8.6) with externalizing scores than did measurements taken at 17–21 weeks (β = 0.6; 95% CI, −2.9 to 4.1). CONCLUSIONS: These results suggest that prenatal BPA exposure may be associated with externalizing behaviors in 2-year-old children, especially among female children.
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spelling pubmed-27994712010-01-04 Prenatal Bisphenol A Exposure and Early Childhood Behavior Braun, Joe M. Yolton, Kimberly Dietrich, Kim N. Hornung, Richard Ye, Xiaoyun Calafat, Antonia M. Lanphear, Bruce P. Environ Health Perspect Research BACKGROUND: Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. OBJECTIVE: We examined the association between prenatal BPA exposure and behavior in 2-year-old children. METHODS: We used data from 249 mothers and their children in Cincinnati, Ohio (USA). Maternal urine was collected around 16 and 26 weeks of gestation and at birth. BPA concentrations were quantified using high-performance liquid chromatography–isotope-dilution tandem mass spectrometry. Child behavior was assessed at 2 years of age using the second edition of the Behavioral Assessment System for Children (BASC-2). The association between prenatal BPA concentrations and BASC-2 scores was analyzed using linear regression. RESULTS: Median BPA concentrations were 1.8 (16 weeks), 1.7 (26 weeks), and 1.3 (birth) ng/mL. Mean (± SD) BASC-2 externalizing and internalizing scores were 47.6 ± 7.8 and 44.8 ± 7.0, respectively. After adjustment for confounders, log(10)-transformed mean prenatal BPA concentrations were associated with externalizing scores, but only among females [β = 6.0; 95% confidence interval (CI), 0.1–12.0]. Compared with 26-week and birth concentrations, BPA concentrations collected around 16 weeks were more strongly associated with externalizing scores among all children (β = 2.9; 95% CI, 0.2–5.7), and this association was stronger in females than in males. Among all children, measurements collected at ≤ 16 weeks showed a stronger association (β = 5.1; 95% CI, 1.5–8.6) with externalizing scores than did measurements taken at 17–21 weeks (β = 0.6; 95% CI, −2.9 to 4.1). CONCLUSIONS: These results suggest that prenatal BPA exposure may be associated with externalizing behaviors in 2-year-old children, especially among female children. National Institute of Environmental Health Sciences 2009-12 2009-10-06 /pmc/articles/PMC2799471/ /pubmed/20049216 http://dx.doi.org/10.1289/ehp.0900979 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Braun, Joe M.
Yolton, Kimberly
Dietrich, Kim N.
Hornung, Richard
Ye, Xiaoyun
Calafat, Antonia M.
Lanphear, Bruce P.
Prenatal Bisphenol A Exposure and Early Childhood Behavior
title Prenatal Bisphenol A Exposure and Early Childhood Behavior
title_full Prenatal Bisphenol A Exposure and Early Childhood Behavior
title_fullStr Prenatal Bisphenol A Exposure and Early Childhood Behavior
title_full_unstemmed Prenatal Bisphenol A Exposure and Early Childhood Behavior
title_short Prenatal Bisphenol A Exposure and Early Childhood Behavior
title_sort prenatal bisphenol a exposure and early childhood behavior
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799471/
https://www.ncbi.nlm.nih.gov/pubmed/20049216
http://dx.doi.org/10.1289/ehp.0900979
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