A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology

Conventional drug design embraces the “one gene, one drug, one disease” philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs that act via polypharmacological mechanisms can produce compounds that exhibit incr...

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Detalles Bibliográficos
Autores principales: Durrant, Jacob D., Amaro, Rommie E., Xie, Lei, Urbaniak, Michael D., Ferguson, Michael A. J., Haapalainen, Antti, Chen, Zhijun, Di Guilmi, Anne Marie, Wunder, Frank, Bourne, Philip E., McCammon, J. Andrew
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799658/
https://www.ncbi.nlm.nih.gov/pubmed/20098496
http://dx.doi.org/10.1371/journal.pcbi.1000648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799658/
https://www.ncbi.nlm.nih.gov/pubmed/20098496
http://dx.doi.org/10.1371/journal.pcbi.1000648

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