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A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology
Conventional drug design embraces the “one gene, one drug, one disease” philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs that act via polypharmacological mechanisms can produce compounds that exhibit incr...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799658/ https://www.ncbi.nlm.nih.gov/pubmed/20098496 http://dx.doi.org/10.1371/journal.pcbi.1000648 |