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A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia
An 82-yr-old man was presented with fever and cough accompanied by generalized erythematous rash. He had taken mexiletine for 5 months, as he had been diagnosed with dilated cardiomyopathy and ventricular arrhythmia. Laboratory studies showed peripheral blood eosinophilia and elevated liver transami...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800002/ https://www.ncbi.nlm.nih.gov/pubmed/20052362 http://dx.doi.org/10.3346/jkms.2010.25.1.148 |
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author | Lee, Sang-Pyo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Yoon, Ho Joo |
author_facet | Lee, Sang-Pyo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Yoon, Ho Joo |
author_sort | Lee, Sang-Pyo |
collection | PubMed |
description | An 82-yr-old man was presented with fever and cough accompanied by generalized erythematous rash. He had taken mexiletine for 5 months, as he had been diagnosed with dilated cardiomyopathy and ventricular arrhythmia. Laboratory studies showed peripheral blood eosinophilia and elevated liver transaminase levels. Chest radiographs showed multiple nodular consolidations in both lungs. Biopsies of the lung and skin lesions revealed eosinophilic infiltration. After a thorough review of his medication history, mexiletine was suspected as the etiologic agent. After discontinuing the mexiletine and starting oral prednisolone, the patient improved, and the skin and lung lesions disappeared. Subsequently, mexiletine was confirmed as the causative agent based on a positive patch test. Drug-induced hypersensitivity syndrome is a severe adverse reaction to drugs and results from treatment with anticonvulsants, allopurinol, sulfonamides, and many other drugs. Several cases of mexiletine-induced hypersensitivity syndrome have been reported in older Japanese males with manifestation of fever, rash, peripheral blood eosinophilia, liver dysfunction without other organ involvement. Here, we report a case of mexiletine-induced hypersensitivity syndrome which presented as eosinophilic pneumonia in a Korean male. |
format | Text |
id | pubmed-2800002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28000022010-01-05 A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia Lee, Sang-Pyo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Yoon, Ho Joo J Korean Med Sci Case Report An 82-yr-old man was presented with fever and cough accompanied by generalized erythematous rash. He had taken mexiletine for 5 months, as he had been diagnosed with dilated cardiomyopathy and ventricular arrhythmia. Laboratory studies showed peripheral blood eosinophilia and elevated liver transaminase levels. Chest radiographs showed multiple nodular consolidations in both lungs. Biopsies of the lung and skin lesions revealed eosinophilic infiltration. After a thorough review of his medication history, mexiletine was suspected as the etiologic agent. After discontinuing the mexiletine and starting oral prednisolone, the patient improved, and the skin and lung lesions disappeared. Subsequently, mexiletine was confirmed as the causative agent based on a positive patch test. Drug-induced hypersensitivity syndrome is a severe adverse reaction to drugs and results from treatment with anticonvulsants, allopurinol, sulfonamides, and many other drugs. Several cases of mexiletine-induced hypersensitivity syndrome have been reported in older Japanese males with manifestation of fever, rash, peripheral blood eosinophilia, liver dysfunction without other organ involvement. Here, we report a case of mexiletine-induced hypersensitivity syndrome which presented as eosinophilic pneumonia in a Korean male. The Korean Academy of Medical Sciences 2010-01 2009-12-29 /pmc/articles/PMC2800002/ /pubmed/20052362 http://dx.doi.org/10.3346/jkms.2010.25.1.148 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Lee, Sang-Pyo Kim, Sang-Heon Kim, Tae Hyung Sohn, Jang Won Shin, Dong Ho Park, Sung Soo Yoon, Ho Joo A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia |
title | A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia |
title_full | A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia |
title_fullStr | A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia |
title_full_unstemmed | A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia |
title_short | A Case of Mexiletine-induced Hypersensitivity Syndrome Presenting as Eosinophilic Pneumonia |
title_sort | case of mexiletine-induced hypersensitivity syndrome presenting as eosinophilic pneumonia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800002/ https://www.ncbi.nlm.nih.gov/pubmed/20052362 http://dx.doi.org/10.3346/jkms.2010.25.1.148 |
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