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The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock
We investigated the use of ulinastatin in association with the suppression of polymorphonuclear leukocyte elastase (PMNE), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and its effects on the prognosis of patients with traumatic hemorrhagic shock. Nineteen patients who visited the em...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800012/ https://www.ncbi.nlm.nih.gov/pubmed/20052358 http://dx.doi.org/10.3346/jkms.2010.25.1.128 |
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author | Park, Kyung Hye Lee, Kang Hyun Kim, Hyun Hwang, Sung Oh |
author_facet | Park, Kyung Hye Lee, Kang Hyun Kim, Hyun Hwang, Sung Oh |
author_sort | Park, Kyung Hye |
collection | PubMed |
description | We investigated the use of ulinastatin in association with the suppression of polymorphonuclear leukocyte elastase (PMNE), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and its effects on the prognosis of patients with traumatic hemorrhagic shock. Nineteen patients who visited the emergency department for traumatic hemorrhagic shock were enrolled. Eleven patients were randomly selected to receive a total of 300,000 IU of ulinastatin. Measurements of serum PMNE, TNF-α and IL-6 were taken before ulinastatin treatment at 24 hr, two days, three days, and seven days after admission. We compared the Systemic Inflammatory Response Syndrome scores, Multiple Organ Dysfunction Syndrome scores and Acute Physiology, age, Chronic Health Evaluation III scores of the control and ulinastatin groups. There were no significant differences in baseline values, laboratory data, treatment or mortality between the two groups. The serum PMNE levels in the ulinastatin group were lower than in the control group on the second hospitalized day. Serum TNF-α and IL-6 levels in the ulinastatin group decreased 24 hr after admission but had no significance. It is suggested that ulinastatin treatment could decrease the serum PMNE levels in trauma patients with hemorrhagic shock at 48 hr after treatment. |
format | Text |
id | pubmed-2800012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28000122010-01-05 The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock Park, Kyung Hye Lee, Kang Hyun Kim, Hyun Hwang, Sung Oh J Korean Med Sci Original Article We investigated the use of ulinastatin in association with the suppression of polymorphonuclear leukocyte elastase (PMNE), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and its effects on the prognosis of patients with traumatic hemorrhagic shock. Nineteen patients who visited the emergency department for traumatic hemorrhagic shock were enrolled. Eleven patients were randomly selected to receive a total of 300,000 IU of ulinastatin. Measurements of serum PMNE, TNF-α and IL-6 were taken before ulinastatin treatment at 24 hr, two days, three days, and seven days after admission. We compared the Systemic Inflammatory Response Syndrome scores, Multiple Organ Dysfunction Syndrome scores and Acute Physiology, age, Chronic Health Evaluation III scores of the control and ulinastatin groups. There were no significant differences in baseline values, laboratory data, treatment or mortality between the two groups. The serum PMNE levels in the ulinastatin group were lower than in the control group on the second hospitalized day. Serum TNF-α and IL-6 levels in the ulinastatin group decreased 24 hr after admission but had no significance. It is suggested that ulinastatin treatment could decrease the serum PMNE levels in trauma patients with hemorrhagic shock at 48 hr after treatment. The Korean Academy of Medical Sciences 2010-01 2009-12-26 /pmc/articles/PMC2800012/ /pubmed/20052358 http://dx.doi.org/10.3346/jkms.2010.25.1.128 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Kyung Hye Lee, Kang Hyun Kim, Hyun Hwang, Sung Oh The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock |
title | The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock |
title_full | The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock |
title_fullStr | The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock |
title_full_unstemmed | The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock |
title_short | The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock |
title_sort | anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800012/ https://www.ncbi.nlm.nih.gov/pubmed/20052358 http://dx.doi.org/10.3346/jkms.2010.25.1.128 |
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