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Phlegmonous colitis: another source of sepsis in cirrhotic patients?
BACKGROUND: The clinical relevance of phlegmonous colitis (PC), a rare autopsy finding in cirrhotic patients, is poorly documented. We postulated that PC might be a source of sepsis in patients with portal hypertensive colopathy (PHC). CASE PRESENTATION: We report three cirrhotic patients who were a...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800109/ https://www.ncbi.nlm.nih.gov/pubmed/20003486 http://dx.doi.org/10.1186/1471-230X-9-94 |
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author | Holzer, Thomas Gervaz, Pascal Spahr, Laurent McKee, Thomas Bucher, Pascal Morel, Philippe |
author_facet | Holzer, Thomas Gervaz, Pascal Spahr, Laurent McKee, Thomas Bucher, Pascal Morel, Philippe |
author_sort | Holzer, Thomas |
collection | PubMed |
description | BACKGROUND: The clinical relevance of phlegmonous colitis (PC), a rare autopsy finding in cirrhotic patients, is poorly documented. We postulated that PC might be a source of sepsis in patients with portal hypertensive colopathy (PHC). CASE PRESENTATION: We report three cirrhotic patients who were admitted with abdominal sepsis and who illustrate, to various degrees, the clinico-pathological sequence of colonic alterations associated with portal hypertension. Two cirrhotic patients with PHC developed gram-negative bacteraemia and quickly responded to intravenous antibiotics. Another cirrhotic patient underwent emergency colectomy for PC, and subsequently died from multiple organ failure. Histological alterations in the operative specimen included: a) mucosal ulcerations; b) disseminated micro-abscesses in the submucosa; and c) a severe vasculopathy leading to complete obliteration of submucosal blood vessels. CONCLUSIONS: These data suggest that cirrhotic patients with PHC may progress towards PC, which, in turn, may be the cause for life-threatening sepsis. |
format | Text |
id | pubmed-2800109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28001092009-12-31 Phlegmonous colitis: another source of sepsis in cirrhotic patients? Holzer, Thomas Gervaz, Pascal Spahr, Laurent McKee, Thomas Bucher, Pascal Morel, Philippe BMC Gastroenterol Case Report BACKGROUND: The clinical relevance of phlegmonous colitis (PC), a rare autopsy finding in cirrhotic patients, is poorly documented. We postulated that PC might be a source of sepsis in patients with portal hypertensive colopathy (PHC). CASE PRESENTATION: We report three cirrhotic patients who were admitted with abdominal sepsis and who illustrate, to various degrees, the clinico-pathological sequence of colonic alterations associated with portal hypertension. Two cirrhotic patients with PHC developed gram-negative bacteraemia and quickly responded to intravenous antibiotics. Another cirrhotic patient underwent emergency colectomy for PC, and subsequently died from multiple organ failure. Histological alterations in the operative specimen included: a) mucosal ulcerations; b) disseminated micro-abscesses in the submucosa; and c) a severe vasculopathy leading to complete obliteration of submucosal blood vessels. CONCLUSIONS: These data suggest that cirrhotic patients with PHC may progress towards PC, which, in turn, may be the cause for life-threatening sepsis. BioMed Central 2009-12-15 /pmc/articles/PMC2800109/ /pubmed/20003486 http://dx.doi.org/10.1186/1471-230X-9-94 Text en Copyright ©2009 Holzer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Holzer, Thomas Gervaz, Pascal Spahr, Laurent McKee, Thomas Bucher, Pascal Morel, Philippe Phlegmonous colitis: another source of sepsis in cirrhotic patients? |
title | Phlegmonous colitis: another source of sepsis in cirrhotic patients? |
title_full | Phlegmonous colitis: another source of sepsis in cirrhotic patients? |
title_fullStr | Phlegmonous colitis: another source of sepsis in cirrhotic patients? |
title_full_unstemmed | Phlegmonous colitis: another source of sepsis in cirrhotic patients? |
title_short | Phlegmonous colitis: another source of sepsis in cirrhotic patients? |
title_sort | phlegmonous colitis: another source of sepsis in cirrhotic patients? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800109/ https://www.ncbi.nlm.nih.gov/pubmed/20003486 http://dx.doi.org/10.1186/1471-230X-9-94 |
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