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Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis
BACKGROUND: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8(+) T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation of cytokines in an FHL patient who was clin...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800185/ https://www.ncbi.nlm.nih.gov/pubmed/20072626 http://dx.doi.org/10.1371/journal.pone.0008663 |