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Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
The breast and ovarian cancer suppressor protein BRCA2 controls the RAD51 recombinase in reactions that lead to homologous DNA recombination (HDR). BRCA2 binds RAD51 via eight conserved BRC repeat motifs of approximately 35 amino acids, each with a varying capacity to bind RAD51. BRC repeats both pr...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800230/ https://www.ncbi.nlm.nih.gov/pubmed/19875419 http://dx.doi.org/10.1093/nar/gkp873 |