Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity

This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adult...

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Autores principales: Chumaeva, Nadja, Hintsanen, Mirka, Ravaja, Niklas, Juonala, Markus, Raitakari, Olli T., Keltikangas-Järvinen, Liisa
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800324/
https://www.ncbi.nlm.nih.gov/pubmed/20049236
http://dx.doi.org/10.3390/ijerph6122934
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author Chumaeva, Nadja
Hintsanen, Mirka
Ravaja, Niklas
Juonala, Markus
Raitakari, Olli T.
Keltikangas-Järvinen, Liisa
author_facet Chumaeva, Nadja
Hintsanen, Mirka
Ravaja, Niklas
Juonala, Markus
Raitakari, Olli T.
Keltikangas-Järvinen, Liisa
author_sort Chumaeva, Nadja
collection PubMed
description This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.
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spelling pubmed-28003242010-01-04 Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity Chumaeva, Nadja Hintsanen, Mirka Ravaja, Niklas Juonala, Markus Raitakari, Olli T. Keltikangas-Järvinen, Liisa Int J Environ Res Public Health Article This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly. Molecular Diversity Preservation International (MDPI) 2009-12 2009-11-27 /pmc/articles/PMC2800324/ /pubmed/20049236 http://dx.doi.org/10.3390/ijerph6122934 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chumaeva, Nadja
Hintsanen, Mirka
Ravaja, Niklas
Juonala, Markus
Raitakari, Olli T.
Keltikangas-Järvinen, Liisa
Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity
title Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity
title_full Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity
title_fullStr Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity
title_full_unstemmed Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity
title_short Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity
title_sort chronic stress and the development of early atherosclerosis: moderating effect of endothelial dysfunction and impaired arterial elasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800324/
https://www.ncbi.nlm.nih.gov/pubmed/20049236
http://dx.doi.org/10.3390/ijerph6122934
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